Results 41 to 50 of about 43,668,679 (193)

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
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Human Immunodeficiency Virus-Infected Individuals Contain Provirus in Small Numbers of Peripheral Mononuclear Cells and at Low Copy Numbers [PDF]

, 1990
In human immunodeficiency virus (HIV)-infected individuals, the proportion of circulating mononuclear cells (PBMCs) which carry HIV provirus and the number of HIV proviral sequences per infected PBMC have been matters for conjecture.
LUDLAM, CA, Leigh Brown, AJ, BISHOP, JO, SIMMONDS, P, BALFE, P, PEUTHERER, JF   +5 more
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Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Nature Communications, 2020
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski, Jordan J. Minnell, Zuzana Hodakova, Valerie E. Pye, Andrea Nans, Peter Cherepanov, Goedele N. Maertens   +6 more
doaj   +1 more source

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Nature Communications, 2021
Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J. Smith, Allison Ballandras-Colas, Nora B. Cronin, Valerie E. Pye, Stephen H. Hughes, Terrence R. Burke, Peter Cherepanov, Goedele N. Maertens   +10 more
doaj   +1 more source

Is the innate bio-protection power against human virus the same between males and females? A conclusion based on blood donor data of HTLV-I infection [PDF]

, 2008
Human T-cell leukemia virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukemia. The male-to-female transmission is stronger than the reverse, so the carrier proportion of women is greater than that of men.
Minoru Tabata, Yasunori Higuchi, Nobuoki Eshima, Shigeru Karukaya   +3 more
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Human T-cell lymphotropic virus type 1 serologic screening tests.

, 2017
Human T-cell lymphotropic virus type 1 serologic screening tests.
Olivier Cassar (463666), Antoine Gessain (31917), Françoise Charavay (3622754), Patricia Jeannin (90882), Frédéric Touzain (3622751), Eliane Chungue (3622745), Jean-Paul Grangeon (184126), Sylvie Laumond (3622757), Paul M. V. Martin (3622748)   +8 more
core   +1 more source

A Machine Learning Approach for MicroRNA Precursor Prediction in Retro-transcribing Virus Genomes

Journal of Integrative Bioinformatics, 2016
Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially
Demirci Müşerref Duygu Saçar, Toprak Mustafa, Allmer Jens   +2 more
doaj   +1 more source

Implementation of nationwide screening of pregnant women for HTLV-1 infection in Japan: analysis of a repeated cross-sectional study

BMC Public Health, 2020
Background Screening of pregnant women carrying human T-lymphotropic virus type 1 (HTLV-1) has a crucial role in reducing the number of HTLV-1 carriers. A national HTLV-1 screening program for pregnant women was started in 2011 in Japan.
Naohiro Yonemoto, Shunji Suzuki, Akihiko Sekizawa, Shinichi Hoshi, Yoko Sagara, Kazuo Itahashi   +5 more
doaj   +1 more source

Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria [PDF]

, 2014
Introduction: Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres in Nigeria, there is no routine pre-transfusion screening for HTLV.
John-olabode, Sarah, Dada, Akinola, Uche, Ebele, Oshinaike, Olajumoke, Okunoye, Olaitan, Akinbami, Akinsegun, Dosunmu, Adedoyin, Adediran, Adewumi, Durojaiye, Idris, Odesanya, Majeed   +9 more
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Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo:implications for models of HIV pathogenesis [PDF]

, 1991
Sequence change in different hypervariable regions of the external membrane glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1) was studied.
Zhang, L Q, Brown, A J, Balfe, P, McOmish, F, Ludlam, C A, Simmonds, P   +5 more
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