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Acute Human T-Lymphotropic Virus Type 1–Associated Myelopathy [PDF]
Archives of Neurology, 2003 Recently, acute human T-lymphotropic virus type 1-associated myelopathy (HAM) was reported clinically without pathologic information. We report an autopsy case of acute HAM.To report the case of a 52-year-old man with acute-onset gait disturbance followed by rapidly progressive paraplegia, who died 9 months later.The postmortem study showed swelling of Naoki, Kasahata, Junichi, Shiota, Yumi, Miyazawa, Imaharu, Nakano, Shigeo, Murayama +4 moreopenaire +2 more sourcesNanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments
VIEW, EarlyView.Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah +5 morewiley +1 more sourceHuman T-Lymphotropic Virus Type 1 Transcription and Chromatin-Remodeling Complexes [PDF]
Journal of Virology, 2010 ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) encodes the viral protein Tax, which is believed to act as a viral transactivator through its interactions with a variety of transcription factors, including CREB and NF-κB. As is the case for all retroviruses, the provirus is inserted into the host DNA, where nucleosomes are deposited to ...Rebecca, Easley, Lawrence, Carpio, Irene, Guendel, Zachary, Klase, Soyun, Choi, Kylene, Kehn-Hall, John N, Brady, Fatah, Kashanchi +7 moreopenaire +2 more sourcesHTLV screening and confirmatory testing among blood donors in São Paulo: A cross‐sectional study
Transfusion Medicine, EarlyView.Abstract Introduction
Human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) are transfusion‐transmissible retroviruses associated with severe diseases, and blood donor screening is mandatory in Brazil. Increasing HTLV‐related discard rates at our institution prompted this study to determine the prevalence and incidence of HTLV‐1/2 and to investigate Suzete C. Ferreira, Anna S. Nishyia, Jerenice E. Ferreira, Claudia Di Lorenzo Oliveira, Cesar de Almeida‐Neto, Tila Fanciani, Katia C. Dantas, Juliana Derriga, Silvia Petrossi Gallo Polato, Nanci Salles, Vanderson Rocha, Alfredo Mendrone‐Junior +11 morewiley +1 more sourceDiseases caused by human T-lymphotropic virus type 1 (HTLV-1)
Microbiology Independent Research JournalINTRODUCTION: Human T-lymphotropic virus type 1 (HTLV-1) belongs to the Retroviridae family (genus Deltaretrovirus ) and is directly involved in carcinogenesis. The HTLV-1 genome is represented by plus-strand RNA, which is transcribed into proviral DNA Lubov V. Radygina, Larisa V. Mochalovadoaj +1 more sourceBurden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case‐Cohort Study
International Journal of Cancer, Volume 159, Issue 5, Page 1282-1295, 1 September 2026.While several oncogenic pathogens cause site‐specific cancers, uncertainties remain about many other chronic infections and combined pathogen effects, especially in non‐Western populations. Using a large case–cohort study nested within the China Kadoorie Biobank, the authors found that co‐infection was common, with a mean of 10 pathogens per individual.Ling Yang, Jonathan Clarke, Lea Kröller, Christiana Kartsonaki, Hannah Fry, Rima Jeske, Andrew Gordon, Sarah Clark, Michael Hill, Daniel Avery, Yiping Chen, Huaidong Du, Jun Lv, Dianjianyi Sun, Canqing Yu, Liming Li, Iona Y. Millwood, Tim Waterboer, Zhengming Chen, on behalf of the China Kadoorie Biobank Collaborative Group, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Liming Li, Jun Lv, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Yuting Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Yiping Chen, Zhengming Chen, Jonathan Clarke, Robert Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Dan Schmidt, Becky Stevens, Iain Turnbull, Robin Walters, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Dan Hu, Xiaoyan Zheng, Yujie Wang, Wei Sun, Shichun Yan, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Tingting Ou, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Yan Xu, Jinyi Zhou, Ran Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Yan Lu, Yujie Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, Ge Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Mingqiang Yuan, Ling Wang, Xiaofang Chen, Zhaodong Wang, Qiang Sun, Yang Lin, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, Li Gao, Shaofang Li, Tianfang Xing, Wei Tang, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Hao Xu, Yuan Cao, Kaixu Xie, Lingli Chen, Xiaomei Tu, Junlong Pan, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Yin, Xian Xie, Jing Wang, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Chan Qu, li Deng, Qili Jiang, Yanling Chen +212 morewiley +1 more sourceMolecular Mechanisms of Electric Signals Generated at Corneal Wounds
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Corneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT
Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.Brian Reid, Guillaume Luxardi, Min Zhaowiley +1 more sourceTargeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aim
Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani +11 morewiley +1 more sourceA Case of Hypercalcemia due to Adult T-Cell Lymphoma
Case Reports in Clinical Practice, 2018 Adult T-cell leukemia (ATL) is the only T-cell lymphoproliferative disease, known to be caused by a virus. While human T-lymphotropic virus type 1 (HTLV-1) is found to cause adult T-cell leukemia, other T-cell neoplastic diseases do not correlate with ...Faeze Moghimpour-Bijani, Sahar Karimpour-Reyhan, Mahsa Abbaszadeh +2 moredoaj Low Prevalence of Human T‐Cell Lymphotropic Virus Type 1 (HTLV‐1) in a Hospital Triage Population in Tehran During 2024–2025
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims
Human T‐cell lymphotropic virus type 1 (HTLV‐1) is a retrovirus that is associated to adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) as two major diseases of the virus.Arash Letafati, Shima Sadeghipour Marvi, Negar Asghari Hosori, Ghazale Molaverdi, Alireza Esfandiari, Nima Afshar Moghadam, Shabnam Siavoshi, Mehdi Norouzi, Sayed‐Hamidreza Mozhgani +8 morewiley +1 more source