Results 31 to 40 of about 47,265,557 (210)

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Nature Communications, 2021
Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J. Smith, Allison Ballandras-Colas, Nora B. Cronin, Valerie E. Pye, Stephen H. Hughes, Terrence R. Burke, Peter Cherepanov, Goedele N. Maertens   +10 more
doaj   +1 more source

Sexual transmission of human T-cell lymphotropic virus type 1

Revista da Sociedade Brasileira de Medicina Tropical, 2014
Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child.
Arthur Paiva, Jorge Casseb
doaj   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source

GUILLAIN-BARRÉ syndrome and hemolytic anemia associated with HTLV-1 infection

Revista de la Facultad de Medicina Humana, 2018
Male patient, 54 years old, with a history of Guillain-Barré syndrome, treated with Gabapentin. Four months before admission presents autoimmune hemolytic anemia, treated with prednisone.
Rául Vallejos Núñez, Luka Serquen-Mora, Rossmery Olortegui-León, Dayanne Benites-Gamboa, José Molina-Quenaya   +4 more
doaj   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
O'Sullivan, K.M., Mothe, B.R., Kalife, ET, Johnston, MN, Altfeld, M., Kalife, E.T., Strick, D.A., Lee, PK, Yu, X.G., Mallal, SA, Walker, B.D., Rosenberg, ES, Mothe, BR, Allen, T.M., Cohen, D.E., Altfeld, M, Sette, A., Walker, BD, Sette, A, John, M., Johnston, M.N., Rosenberg, E.S., O'Sullivan, KM, Le Gall, S, Allen, TM, Brander, C, John, M, Goulder, P.J.R., Brander, C., Goulder, PJ, Lichterfeld, M, Freedberg, K.A., Cohen, DE, Freedberg, KA, Mallal, S.A., Lee, P.K., Yu, XG, Le Gall, S., Lichterfeld, M., Strick, DA   +39 more
core   +1 more source

Defective human T‐lymphotropic virus type 1 provirus in asymptomatic carriers [PDF]

International Journal of Cancer, 2011
AbstractFew studies have specifically examined defective provirus in asymptomatic human T‐lymphotropic virus Type 1 (HTLV‐1) carriers and its relation to proviral DNA loads (PVLs). To assess the significance of defective provirus in asymptomatic carriers, we examined PVLs in peripheral blood mononuclear cells of 208 asymptomatic HTLV‐1 carriers.
Hiroyuki, Takenouchi, Kazumi, Umeki, Daisuke, Sasaki, Ikuo, Yamamoto, Hajime, Nomura, Ichiro, Takajo, Shiro, Ueno, Kunihiko, Umekita, Shimeru, Kamihira, Kazuhiro, Morishita, Akihiko, Okayama   +10 more
openaire   +2 more sources

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Nature Communications, 2020
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski, Jordan J. Minnell, Zuzana Hodakova, Valerie E. Pye, Andrea Nans, Peter Cherepanov, Goedele N. Maertens   +6 more
doaj   +1 more source

Human T lymphotropic virus types 1 and 2: a point of view [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2013
Reported at the beginning of the 1980s, Human T lymphotropic viruses type 1 and 2 (HTLV1, HTLV 2) were the first retroviruses to have been detected in human beings. HTLV 1 was isolated from adult T-cell leukemia (ATL) and first described by Takatsuki et al. in Japan in 1976, as a malignancy that only affects T cells and only in adults(1, 2).
openaire   +4 more sources

Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study

Open Chemistry, 2023
This study aimed to evaluate the prevalence and trends of transfusion-transmitted infections (TTIs) in two hospitals in Riyadh, as well as to judge the best type of tests to ensure blood transfusion safety. By using serological and nucleic acid test (NAT)
Mubaraki Murad A., Almuayrifi Hussain A., Hafiz Taghreed A., Alyousef Abdulaziz, Dkhil Mohamed A., Thagfan Felwa A., Abdel-Gaber Rewaida, Al-Najjar Mohammad A. A., Alkhudhayri Abdulsalam, Elshanat Sherif   +9 more
doaj   +1 more source

Acute Human T-Lymphotropic Virus Type 1–Associated Myelopathy [PDF]

Archives of Neurology, 2003
Recently, acute human T-lymphotropic virus type 1-associated myelopathy (HAM) was reported clinically without pathologic information. We report an autopsy case of acute HAM.To report the case of a 52-year-old man with acute-onset gait disturbance followed by rapidly progressive paraplegia, who died 9 months later.The postmortem study showed swelling of
Naoki, Kasahata, Junichi, Shiota, Yumi, Miyazawa, Imaharu, Nakano, Shigeo, Murayama   +4 more
openaire   +2 more sources