Results 51 to 60 of about 38,210 (254)

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1. [PDF]

, 2013
Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but ...
Boasso, A
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Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study

Open Chemistry, 2023
This study aimed to evaluate the prevalence and trends of transfusion-transmitted infections (TTIs) in two hospitals in Riyadh, as well as to judge the best type of tests to ensure blood transfusion safety. By using serological and nucleic acid test (NAT)
Mubaraki Murad A., Almuayrifi Hussain A., Hafiz Taghreed A., Alyousef Abdulaziz, Dkhil Mohamed A., Thagfan Felwa A., Abdel-Gaber Rewaida, Al-Najjar Mohammad A. A., Alkhudhayri Abdulsalam, Elshanat Sherif   +9 more
doaj   +1 more source

Human T-lymphotropic virus and transfusion safety. Does one size fit all? [PDF]

, 2015
Human T-cell leukemia viruses (HTLV-1 and HTLV-2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable.
Catalano, Liviana, Facco, Giuseppina, Grazzini, Giuliano, Liumbruno, Giancarlo Maria, Marano, Giuseppe, Piccinini, Vanessa, Pupella, Simonetta, VAGLIO, Stefania   +7 more
core   +1 more source

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Nature Communications, 2020
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski, Jordan J. Minnell, Zuzana Hodakova, Valerie E. Pye, Andrea Nans, Peter Cherepanov, Goedele N. Maertens   +6 more
doaj   +1 more source

High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease. [PDF]

, 2015
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL).
A Gessain, A Gessain, AH Smith, AM Vine, CR Bangham, D Weycker, E Gotuzzo, EL Murphy, F Okada, Graham P Taylor, H Kawai, H Merle, H Nakamura, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, J Crofton, JR Orland, K Nishioka, L Einsiedel, L Einsiedel, L Einsiedel, L LaGrenade, M Nagai, M Nakagawa, M Osame, M Sugimoto, M Sugimoto, MA Demontis, MG Flynn, OS Morgan, PJ McShane, S Mita, S Mori, Shohreh Honarbakhsh, T Arakaki, T Kondo, T Matsuda, T Yamashiro, W Matsuyama   +37 more
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Human T lymphotropic virus types 1 and 2: a point of view [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2013
Reported at the beginning of the 1980s, Human T lymphotropic viruses type 1 and 2 (HTLV1, HTLV 2) were the first retroviruses to have been detected in human beings. HTLV 1 was isolated from adult T-cell leukemia (ATL) and first described by Takatsuki et al. in Japan in 1976, as a malignancy that only affects T cells and only in adults(1, 2).
openaire   +4 more sources

Acute Human T-Lymphotropic Virus Type 1–Associated Myelopathy [PDF]

Archives of Neurology, 2003
Recently, acute human T-lymphotropic virus type 1-associated myelopathy (HAM) was reported clinically without pathologic information. We report an autopsy case of acute HAM.To report the case of a 52-year-old man with acute-onset gait disturbance followed by rapidly progressive paraplegia, who died 9 months later.The postmortem study showed swelling of
Naoki, Kasahata, Junichi, Shiota, Yumi, Miyazawa, Imaharu, Nakano, Shigeo, Murayama   +4 more
openaire   +2 more sources

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms [PDF]

, 2007
Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Burmeister, Thomas, Schwartz, Stefan, Hummel, Michael, Hoelzer, Dieter (Prof. Dr.), Thiel, Eckhard   +4 more
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Defective human T‐lymphotropic virus type 1 provirus in asymptomatic carriers [PDF]

International Journal of Cancer, 2011
AbstractFew studies have specifically examined defective provirus in asymptomatic human T‐lymphotropic virus Type 1 (HTLV‐1) carriers and its relation to proviral DNA loads (PVLs). To assess the significance of defective provirus in asymptomatic carriers, we examined PVLs in peripheral blood mononuclear cells of 208 asymptomatic HTLV‐1 carriers.
Hiroyuki, Takenouchi, Kazumi, Umeki, Daisuke, Sasaki, Ikuo, Yamamoto, Hajime, Nomura, Ichiro, Takajo, Shiro, Ueno, Kunihiko, Umekita, Shimeru, Kamihira, Kazuhiro, Morishita, Akihiko, Okayama   +10 more
openaire   +2 more sources

How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

, 2015
A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome ...
Bangham, CRM, Ratner, L
core   +1 more source