Results 251 to 260 of about 8,929,565 (386)

Intracellular Localization and Trafficking of Fluorescein-Labeled Cisplatin in Human Ovarian Carcinoma Cells [PDF]

open access: bronze, 2005
Roohangiz Safaei   +8 more
openalex   +1 more source

Adiponectin Assists Thrombopoietic Agents in ITP Treatment by Enhancing Myosin‐9/Rab6A‐Mediated Trafficking of c‐Mpl in MKs

open access: yesAdvanced Science, EarlyView.
This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao   +8 more
wiley   +1 more source

A Teach-the-Teacher Module for Human Trafficking Bedside Instruction. [PDF]

open access: yesMedEdPORTAL
Young A   +9 more
europepmc   +1 more source

Assessing healthcare provider knowledge of human trafficking. [PDF]

open access: yesPLoS One, 2022
Exeni McAmis NE   +7 more
europepmc   +1 more source

Intracellular Trafficking of CD23: Differential Regulation in Humans and Mice by Both Extracellular and Intracellular Exons [PDF]

open access: bronze, 2005
Guillaume Montagnac   +6 more
openalex   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang   +10 more
wiley   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

open access: yesAdvanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan   +16 more
wiley   +1 more source

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