Results 91 to 100 of about 25,586,963 (298)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

3D Video Enhancement Based on Human Visual System Characteristics

, 2010
The most emerging video technologies for cultural and social activities refer to 3D visual data processing and rendering. In fact, the use of 3D images and videos allows end-users to benefit from a depth perception of the recorded scene, being thus ...
MAIORANA, EMANUELE, NERI, Alessandro, BATTISTI, FEDERICA, CAMPISI, PATRIZIO   +3 more
core  

On the Neuronal Activity in the Human Brain During Visual Recognition, Imagery and Binocular Rivalry [PDF]

, 2002
How does the neuronal activity in our brains give rise to our perceptions? We recorded the electrophysiological activity of over one thousand individual neurons in the human brain during object recognition, binocular rivalry, visual imagery and sleep ...
Kreiman, Gabriel Alejandro
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Visual Tools for Natural Language Processing [PDF]

, 2001
We describe GATE, the General Architecture for Text Engineering, an integrated visual development environment to support the visual assembly, execution and analysis of modular natural language processing systems.
Humphreys, Kevin, Rodgers, Peter, Gaizauskas, Robert   +2 more
core   +1 more source

A New Human Perception-Based Over-Exposure Detection Method for Color Images

Sensors, 2014
To correct an over-exposure within an image, the over-exposed region (OER) must first be detected. Detecting the OER accurately has a significant effect on the performance of the over-exposure correction.
Yeo-Jin Yoon, Keun-Yung Byun, Dae-Hong Lee, Seung-Won Jung, Sung-Jea Ko   +4 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Multi-timescale perceptual history resolves visual ambiguity. [PDF]

, 2008
When visual input is inconclusive, does previous experience aid the visual system in attaining an accurate perceptual interpretation? Prolonged viewing of a visually ambiguous stimulus causes perception to alternate between conflicting interpretations ...
Brascamp, JW, Knapen, THJ, van Ee, R, van den Berg, AV, van den Berg, A.V., Noest, AJ, Dep Biologie, Kanai, R, Brascamp, J.W., Afd Psychologische functieleer, Knapen, T.H.J., Physics of Man (Perceptual Motor Integration), Neural models in human perception: saccadic search, haptic search and perceptual rivalry, Dep Natuurkunde, Noest, A.J., Kanai, R., van Ee, R.   +16 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Multi-sensor human action recognition with particular application to tennis event-based indexing [PDF]

, 2013
The ability to automatically classify human actions and activities using vi- sual sensors or by analysing body worn sensor data has been an active re- search area for many years. Only recently with advancements in both fields and the ubiquitous nature of
Connaghan, Damien
core   +2 more sources