Results 91 to 100 of about 821,688 (312)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
An edge detection algorithm based on Human Visual System
, 2013 Edge detection is a fundamental problem in computer vision. In this paper, we present an effective algorithm to find salient edges from infrared scene images based on Human Visual System. The algorithm integrates three basic edge features: edge contrast,
Xia RB(夏仁波) +2 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Learning visual biases from human imagination
, 2015 Although the human visual system can recognize many concepts under challengingconditions, it still has some biases. In this paper, we investigate whether wecan extract these biases and transfer them into a machine recognition system.We introduce a novel ...
Vondrick, Carl Martin +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Emergence of perceptual Gestalts in the human visual cortex: The case of the configural superiority effect [PDF]
, 2011 Many Gestalt phenomena have been described in terms of perception of a whole being not equal to the sum of its parts. It is unclear how these phenomena emerge in the brain.
Op de Beeck, Hans P. (5265106) +5 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
3D Video Enhancement Based on Human Visual System Characteristics
, 2010 The most emerging video technologies for cultural and social activities refer to 3D visual data processing and rendering. In fact, the use of 3D images and videos allows end-users to benefit from a depth perception of the recorded scene, being thus ...
MAIORANA, EMANUELE +3 more
core
Multi-sensor human action recognition with particular application to tennis event-based indexing [PDF]
, 2013 The ability to automatically classify human actions and activities using vi- sual sensors or by analysing body worn sensor data has been an active re- search area for many years. Only recently with advancements in both fields and the ubiquitous nature of
Connaghan, Damien
core