Results 81 to 90 of about 821,688 (312)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Human Eye Visualization With an Attention Mechanism: Enhancing Flower Detection and Classification With Visual Attention and Photometric Principles Inspired by Human Vision

Engineering Reports
In this paper, a visual attention network (VANet) that draws inspiration from the complex workings of the human visual system is presented. The human eye possesses an extraordinary capacity to selectively concentrate on particular features within a scene
Arpan Singh, C. K. Yogesh, Christy Jackson Joshua   +2 more
doaj   +1 more source

Novel Tone Mapping Method via Macro-Micro Modeling of Human Visual System

IEEE Access, 2019
Tone mapping(TM) aims to adapt high dynamic range (HDR) images to conventional displays with visual information preserved. In this paper, a novel TM method based on macro-micro modeling is proposed, which can address the common problems in existing TM ...
Disheng Miao, Zhongjie Zhu, Yongqiang Bai, Gangyi Jiang, Zhiyong Duan   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Nonstimulated early visual areas carry information about surrounding context [PDF]

, 2010
Even within the early sensory areas, the majority of the input to any given cortical neuron comes from other cortical neurons. To extend our knowledge of the contextual information that is transmitted by such lateral and feedback connections, we ...
Lars Muckli, Smith, F.W., Muckli, L., Fraser W. Smith   +3 more
core   +1 more source

Multifocus Image Fusion Based on Extreme Learning Machine and Human Visual System

IEEE Access, 2017
Multifocus image fusion generates a single image by combining redundant and complementary information of multiple images coming from the same scene. The combination includes more information of the scene than any of the individual source images.
Yong Yang, Mei Yang, Shuying Huang, Yue Que, Min Ding, Jun Sun   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Studying feature specific mechanisms of the human visual system

, 2010
What are the current limits of our knowledge of brain activity underlying vision and can I further this knowledge? In this thesis, I explore this basic question.
Kaul, C.E.
core  

A Distorted-Image Quality Assessment Algorithm Based on a Sparse Structure and Subjective Perception

Mathematics
Most image quality assessment (IQA) algorithms based on sparse representation primarily focus on amplitude information, often overlooking the structural composition of images.
Yang Yang, Chang Liu, Hui Wu, Dingguo Yu
doaj   +1 more source