Results 61 to 70 of about 821,688 (312)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

On temporal hyperacuity in the human visual system

Vision Research, 2002
The spatial grain of the human visual system has always been a central topic for visual sciences, and the optical and physiological basis of perceptual limitations are well described. In particular, we have thorough accounts of spatial hyperacuity, which refers to a precision in the spatial localisation of stimulus contours that is better than the ...
Zanker, J.M, Harris, J.P
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A Perceptual Rate Control Algorithm Based on JND for Screen Content Video

Sensors
The rate control algorithm is designed for natural video by default in video-coding standards. However, computer-generated screen content video (SCV) is very different from natural video captured by a camera, with many different statistical ...
Huijie Zheng, Jing Chen, Qi Lin
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Orientational anisotropy in the human visual system [PDF]

Perception & Psychophysics, 1985
A global pattern/randomness threshold was used to investigate orientational anisotropy in the human visual system. Dynamic transpositionally symmetric textures were used, since they allowed the investigation of three theoretically derived variables, size, orientational uniformity, and numerosity, independently and in interaction.
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools [PDF]

, 2011
Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic ...
van den Bosch, Jasper J F, Wolf Singer, van den Bosch, J.J.F., Kohler, A., Kaiser, J., Kaiser, Jochen, Ven, Vincent van de, Marcus J. Naumer, Bosch, Jasper J. F. van den, van de Ven, Vincent, Lars Muckli, Muckli, L., Kohler, Axel, Singer, Wolf, Axel Kohler, Jochen Kaiser, Naumer, M.J., van den Bosch, J., Muckli, Lars, Wibral, M., Wibral, Michael, Michael Wibral, Jasper J. F. van den Bosch, Naumer, Marcus Johannes, Vincent van de Ven, Naumer, Marcus J, van de Ven, V., Singer, W.   +27 more
core   +1 more source

Optimal Implementation of Dynamical Visual Cryptography Scheme for Imaging-Based Testing of Human Visual System

Mathematics
Dynamic visual cryptography (DVC) can be formulated as a discrete-time reconstruction problem for time-averaged moiré fringes generated by oscillatory transformations of periodic gratings.
Loreta Saunoriene, Paulius Palevicius, Arvydas Gelzinis, Minvydas Ragulskis   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source