Results 91 to 100 of about 223,141 (305)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Factors affecting the accuracy of prehospital triage application and prehospital scene time in simulated mass casualty incidents

open access: yesScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background The contemporary management of mass casualty incidents (MCIs) relies on the effective application of predetermined, dedicated response plans based on current best evidence. Currently, there is limited evidence regarding the factors influencing
Luca Carenzo   +7 more
doaj   +1 more source

Mortality in Darfur: Lessons for Humanitarian Policy [PDF]

open access: yes
In recent years there has been considerable debate over how best to formulate reliable estimates of conflict mortality rates. However, in formulating humanitarian policy to respond to violent conflicts it is important to go beyond crude mortality rates ...
Olivier Degomme
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessing the impact of humanitarian assistance in the health sector

open access: yesEmerging Themes in Epidemiology, 2004
There have been significant improvements in the design and management of humanitarian aid responses in the last decade. In particular, a significant body of knowledge has been accumulated about public health interventions in emergencies, following calls ...
Roberts Les, Hofmann Charles-Antoine
doaj   +1 more source

Caring in crisis – why development and humanitarian NGOs need to change how they relate to the public [PDF]

open access: yes, 2014
This post was written by Dr Shani Orgad from the Department of Media and Communications at LSE and Dr Bruna Seu, Department of Psychosocial Studies, Birkbeck.
Orgad, Shani, Seu, Bruna
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Australia in the UN Security Council [PDF]

open access: yes
Overview: In this Lowy Institute Analysis, Richard Gowan reviews Australia’s time as a non-permanent member of the Security Council. Gowan argues that while it has not changed the world, Australia has acquitted itself well, bringing extra rigour and ...
Richard Gowan
core  

MODEL DISTRIBUSI BANTUAN LOGISTIK KEMANUSIAAN PADA SAAT BENCANA BANJIR DENGAN MEMPERHITUNGKAN DATA IKLIM (STUDI KASUS BENCANA BANJIR BANDANG KEC. TANGSE, KAB. PIDIE, PROP. ACEH) [PDF]

open access: yes, 2015
This Floods in Tangse incident which occurred repeatedly in 2011 and 2012 indicate a weakness in the implementation of humanitarian logistic distribution.
Nancy Luciana Damanik
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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