Results 101 to 110 of about 15,276 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Factors associated with international humanitarian aid appeal for disasters from 1995 to 2015: A retrospective database study. [PDF]

PLoS One, 2023
Cheng L, Hertelendy AJ, Hart A, Law LS, Hata R, Nouaime G, Issa F, Echeverri L, Voskanyan A, Ciottone GR.   +9 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Psychosocial model of burnout among humanitarian aid workers in Bangladesh: role of workplace stressors and emotion coping. [PDF]

Confl Health, 2023
Foo CYS, Tay AK, Yang Y, Verdeli H.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

L’aide humanitaire de l’Union européenne au Mali : mythe ou réalité ? (2012-2022) [PDF]

Revue Hybrides
The choice of EU humanitarian aid in Mali is explained, on the one hand, by the fact that this country has been facing an acute humanitarian crisis since the outbreak of the political and security crisis in 2012.
Bouakary OUATTARA
doaj  

From food to cash assistance: rethinking humanitarian aid in Yemen. [PDF]

J Int Humanit Action, 2022
Elayah M, Gaber Q, Fenttiman M.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Understanding leadership challenges faced by humanitarian aid workers: insights from the experiences of NNPHL training participants

Journal of International Humanitarian Action
This paper examines the self-reported leadership challenges experienced by humanitarian aid workers who participated in the National NGO Program on Humanitarian Leadership (NNPHL) Program.
Godfred Nyarko, Ariana Marnicio, Vincenzo Bollettino   +2 more
doaj   +1 more source

Health trajectories of international humanitarian aid workers: growth mixture modelling findings from a prospective cohort study. [PDF]

BJPsych Open, 2023
de Jong K, Martinmäki SE, Te Brake H, Komproe I, Kleber RJ, Haagen JFG.   +5 more
europepmc   +1 more source