Results 101 to 110 of about 219,139 (352)

Psychiatric drugs dispensing trends in the affected population following Brumadinho dam failure

open access: yesFrontiers in Public Health
IntroductionIn January 2019 D1 tailing Dam Failed in Brumadinho, Minas Gerais, Brazil. Two hundred and seventy people were immediately killed when 11.7 million cubic meters of mining byproducts were released, promoting major destruction and environmental
Marcelo Farah Dell'Aringa   +9 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Shades of humanity: state sovereignty and humanitarian principles in the Syrian civil war

open access: yesJournal of International Humanitarian Action
In the Syrian civil war, the Syrian government has imposed numerous restrictions and employed violence to assert its sovereignty in humanitarian action, creating significant challenges for humanitarian aid organizations.
Ümit Seven
doaj   +1 more source

Assessing the allocation of Italian foreign aid [PDF]

open access: yes
This paper provides an assessment of Italian aid policy during the period 1983-2006. In comparison with other donors (DAC and G-7), the main stylized facts are: persistently lower aid/GDP ratio, greater recourse to multilateral channels, a higher ...
Claudia Maurini, Riccardo Settimo
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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