Results 61 to 70 of about 14,586 (245)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Analyzing Humanitarian Intervention from an African Point of View
Vestnik RUDN. International Relations, 2012 The article analyzes the concept of humanitarian intervention from the African perspectives, owing to the none existed of agreed definition or codification of this concept in international law, it has continued to generate considerable interest among ...
- Okoh ThankGod Emeka
doaj
Humanitarian Intervantion: The Principle of Responsibility to Protect (R2P)
Jurnal Hubungan Internasional, 2015 This article describes the notion of the Responsibility to Protect (R2P) as a branch of humanitarian intervention. This approach emerges to immediately respond atrocities of innocent people due to political persecution taking place in a state. R2P allows
Muhammad Zahrul Anam
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Humanitarian Intervention and the Changing Concepts of Sovereignty
Politikon, 2004 U.N. Secretary General Kofi Annan recently observed that "state sovereignty, in its most basic sense, is being redefined ... by the forces of globalisation and international cooperation." The article deals with the question of how much this is an ...
Dominika Švarc
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Book Review: Aidan Hehir, Humanitarian Intervention (Palgrave Macmillan, 2009)
Merkourios, 2011 Gentian Zyberi
doaj +3 more sources