Results 111 to 120 of about 730,113 (317)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From Knowledge to Wisdom: Assessment and Prospects after Three Decades [PDF]
Integral Review, 2013 We are in a state of impending crisis. And the fault lies in part with academia. For two centuries or so, academia has been devoted to the pursuit of knowledge and technological know-how. This has enormously increased our power to act which has, in turn,
Nicholas Maxwell
doaj
Engaged Scholar Journal: Community-Engaged Research, Teaching, and Learning, 2018 Since 2007, the Humanities for Humanity (“H4H”) course has brought together student experience beyond the classroom, educational experiences for community members who could not otherwise attend university, discussion of social justice, and studies in the humanities.
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Digital Publishing in the Arts and Humanities
, 2012 Digital Publishing in the Arts and Humanities in four parts. [Part One:] Digital Publishing in the Arts and Humanities: An Overview (Melanie Schlosser).
Carlson, Wayne +2 more
core
An examination of the physical and the digital qualities of humanities research
, 2008 Traditionally humanities scholars have worked in physical environments and with physical artefacts. Libraries are familiar places, built on cultural traditions over thousands of years, and books are comfortable research companions.
Rimmer, J +9 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 2007 The following paper presents a case study of the way that the research done by the LAIRAH project may be applied in the case of a real digital resource for humanities scholarship.
C. Warwick +14 more
core
What is the role of the humanities at the start of 21st century? In the last few decades, the various disciplines of the humanities (history, linguistics, literary studies, art history, media studies) have encountered a broad range of challenges, related
core +1 more source