Results 131 to 140 of about 944,399 (257)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Identidade profissional e as humanidades na Famed/UFU

Revista Brasileira de Educação Médica
Este ensaio aborda a identidade no âmbito da educação, em particular a identidade profissional do médico e suas relações com o curso de formação em Medicina da Universidade Federal de Uberlândia (UFU).
Alfredo Demétrio Jorge Neto
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Evaluating digital humanities resources: The LAIRAH project checklist and the internet Shakespeare editions project [PDF]

, 2007
The following paper presents a case study of the way that the research done by the LAIRAH project may be applied in the case of a real digital resource for humanities scholarship.
C. Warwick, P. Huntington, Warwick, C., M. Terras, Terras, M., Warwick, C, Huntington, P., Terras, M, Huntington, P, I. Galina, M. Pappa, Galina, I., Pappa, N, Pappa, N., Galina, I   +14 more
core  

Digital Publishing in the Arts and Humanities

, 2012
Digital Publishing in the Arts and Humanities in four parts. [Part One:] Digital Publishing in the Arts and Humanities: An Overview (Melanie Schlosser).
Carlson, Wayne, Schlosser, Melanie, Selfe, Cynthia   +2 more
core   +1 more source

Slopek, Edward. Bodies of Art: The Shaping of Aesthetic Experience

Belphégor, 2022
Marie Pascal
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Constitution and By-Laws of the Federation of Public Programs in the Humanities

, 1977
Federation of State Humanities Councils original constitution and by ...
Federation of Public Programs in the Humanities
core