Results 121 to 130 of about 1,389,305 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Humans, Humanities, and Humanism in an Age of Technology [PDF]
, 2016 Harry Potter’s world as described by J.K. Rowling in a series of books for children is not the world of us, ordinary humans.1 Owls delivering letters overnight would be handy. Howling letters that criticize their recipients in public might be embarrassing.
openaire +2 more sources
The Mickey Mouse world of humanities scholarship [PDF]
, 2000 Looks at the contradiction between commercial needs and scholarship such as in the area of copyright. Proposes the need for a serious debate on what is required from an electronic environment for scholarship, then act to set about constructing it.
Law, Derek
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Humans raised by humans raised by humans
, 2018 Humans Raised by Humans Raised by Humans is a collection of poems concerned with inheritance, particularly the things we inherit without knowing that emerge and unravel at unexpected times.
Killmeyer, Sam, author +3 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
China and the Humanities: At the Crossroads of the Human and the Humane [PDF]
, 2013 This contains the sections of this volume produced by the editor, including the front matter, Preface, Introduction and Index.
openaire +1 more source
The Palaeographical Method under the Light of a Digital Approach [PDF]
, 2009 This paper has the twofold aim of reflecting upon a humanities computing approach to palaeography, and of making such reflections - together with its related experimental results - fruitful at the implementation level.
Ciula, Arianna
core