Results 121 to 130 of about 1,288,714 (407)

Learning Representations by Humans, for Humans

open access: yes, 2019
We propose a new, complementary approach to interpretability, in which machines are not considered as experts whose role it is to suggest what should be done and why, but rather as advisers. The objective of these models is to communicate to a human decision-maker not what to decide but how to decide.
Banaji , Mahzarin   +4 more
openaire   +5 more sources

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Why Do We Need Humanities? [PDF]

open access: yes, 2017
The article is a philosophical reflection of the current status of the humanities in Slovakia. In many areas of our society there is an evident deficit in humanities-science knowledge, reflected also in parliamentary election results in 2016 and having ...
Švihura, Lukáš
core  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

2017 ‘Why Humanities?’ Finalist: A Letter to My Past Self [PDF]

open access: yes, 2017
In a letter to her 18-year-old self, 2017 finalist of the University of Windsor’s Humanities Research Group’s ‘Why Humanities?’ undergraduate essay/creative project contest, Aline Nguyen reassures their younger self that pursuing a passion for teaching ...
Nguyen, Aline
core   +1 more source

When Two Worlds Meet: A Response to Heesters

open access: yesBioéthiqueOnline, 2015
This is a commentary on the article of Heesters, “Healthy as a trout – as delicate as a dragon-fly”, in which she describes her experience of illness. Her text shows that there are two worlds that are difficult to reconcile: that of caregivers and sick ...
Quintin, Jacques
doaj  

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

Overview of International Household Panel Studies. Statement of the German Council of Science and Humanities on the Status and Future Development of the German Socio-Economic Panel (SOEP). November 13, 2009. Appendix 6 [PDF]

open access: yes
In July 2007, the German Federal Ministry of Education and Research (BMBF) requested that the German Council of Science and Humanities (Wissenschaftsrat) develop recommendations on improving Germany’s scientific infrastructure in the Humanities and ...
German Council of Science and Humanities
core  

Nation Building and the Politics of Islamic Internationalism in Guinea: Toward an Understanding of Muslims’ Experience of Globalization in Africa [PDF]

open access: yes, 2007
This article discusses the historical role of Islam in the political evolution of Guinea in the broader context of Muslims’ experience of nation/state building and globalization in Africa.
Camara, Mohamed S.
core   +1 more source

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