Results 121 to 130 of about 957,320 (315)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Scientific ReportsAcute ischemic stroke (AIS) remains a major cause of global morbidity and mortality. This study aimed to evaluate the role of albumin corrected anion gap (ACAG) as a prognostic marker for AIS patients. We analyzed data from 1014 AIS patients in the MIMIC-
Yaxin Zhang +5 more
doaj +1 more source
Kant and Consequentialism (Reflections on Cummiskey’s Kantian Consequentialism) [PDF]
, 2018 In his article, the author considers possible forms of relationship between Kant’s ethics and consequentialism. In this context, he analyses David Cummiskey’s views which are expressed in his book, Kantian Consequentialism ...
Gluchman, Vasil
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Understanding How the Privileged Become Violent Fanatics [PDF]
The great British biologist J.B.S Haldane counted monotheism's creation of fanaticism as one of the most important inventions of the last 5,000 years. Call it love of God or love of group, it matters little in the end.
Scott Atran
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Postage Due: Stewardship, Stamps and a Watch Pocket [PDF]
, 2014 Why do we forget that people are human? I\u27ve been asking myself that question more and more lately. Partially it\u27s driven by a laundry list of things happening in the world, vitriolic attacks on humanity, both strangers and friends.
Rudy, John M.
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
From Tolerance and Diversity to Inclusion and Celebration; New Horizons for Infusing Queer Theory into Communities [PDF]
, 2017 Tolerance and diversity are at times lauded as the essential terms for modern social justice movements. From school to community settings teachers, public figures, and political leaders throw these terms around to great applaud and acclaim.
McGuire, Laura Jean
core +1 more source