Results 131 to 140 of about 1,090,985 (351)

Kant and Consequentialism (Reflections on Cummiskey’s Kantian Consequentialism) [PDF]

, 2018
In his article, the author considers possible forms of relationship between Kant’s ethics and consequentialism. In this context, he analyses David Cummiskey’s views which are expressed in his book, Kantian Consequentialism ...
Gluchman, Vasil
core  

Scientists’ warning to humanity on the freshwater biodiversity crisis

Ambio, 2020
J. Albert, G. Destouni, S. Duke-Sylvester, A. Magurran, T. Oberdorff, R. Reis, K. Winemiller, W. Ripple   +7 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Serum albumin corrected anion gap levels are associated with poor prognosis in patients with acute ischemic stroke

Scientific Reports
Acute ischemic stroke (AIS) remains a major cause of global morbidity and mortality. This study aimed to evaluate the role of albumin corrected anion gap (ACAG) as a prognostic marker for AIS patients. We analyzed data from 1014 AIS patients in the MIMIC-
Yaxin Zhang, Fan Wu, Jiawei Sun, Chuchuan Xu, Qingwei Yang, Guangdong Wang   +5 more
doaj   +1 more source

Because We Smile: Jonathan Swift\u27s Enthusiastic Magnifying Glass [PDF]

, 2005
Jonathan Swift (1667-1745) was intellectually before his time. His insights into the human condition reveal a belief in the not-hopeless corruption of humanity.
Mink, Jared Timothy
core   +1 more source

Reducing the risks of nuclear war to humanity

The Lancet, 2022
Ira Helfand, P. Lewis, A. Haines
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Why care for humanity?

Royal Society Open Science
Some of the most pressing challenges facing our planet—such as climate change, biodiversity loss, warfare and extreme poverty—require social cohesion and prosocial action on a global scale. How can this be achieved?
Lukas Reinhardt, Harvey Whitehouse
doaj   +1 more source

On Eternal Punishment: A Brief Dialogue [PDF]

In this brief dialogue I consider the humanity and morality of the doctrine of eternal ...
Oxenberg, Richard
core  

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source