Results 81 to 90 of about 968,843 (363)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Human-Centered Humanities

Digital Humanities in the Nordic and Baltic Countries Publications, 2020
This pilot study proposes the use of so-called stimulus material during interviews for requirements elicitation as part of the design process of a digital archive. Designing complex systems like digital archives is not straightforward as users of these systems have specific needs and tasks that designers need to be aware of before the implementation ...
Tamás Fergencs, Dominika Illés, Olga Pilawka, Florian Meier   +3 more
openaire   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A study on the impact of operational efficiency of policy-oriented agricultural insurance on farmers’ income: evidence from major grain-producing areas in China

Frontiers in Sustainable Food Systems
IntroductionEnsuring food security and stabilizing farmers’ income are very important for China’s development, and policy-oriented agricultural insurance is an important risk management tool led by the government.
Kechen Song, Ke Li, Mei Sun
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Epidemic Response and Reflections on the 1918—1919 Influenza Pandemic in Shanghai

Yixue yu zhexue
Shanghai, as one of the first cities in China to undergo modernization, was severely affected by the 1918—1919 influenza pandemic, experiencing three waves of the epidemic in the summer of 1918, the autumn of 1918, and the spring of 1919.
Hongyu CHEN, Yuan YUAN
doaj   +1 more source

Water purification using porous ceramics prepared by recycling volcanic ash and waste glass

Applied Water Science, 2017
Water purification was examined using porous ceramics prepared by sintering a powder mixture of volcanic ash, waste glass and a small amount of wood charcoal.
Tomohiro Ando, Yuki Fujita, Mayu Kakinaga, Nobuto Oka, Tetsuaki Nishida   +4 more
doaj   +1 more source

The Cradle of Humanity: A Psychological and Phenomenological Perspective [PDF]

, 2017
We present an account of the evolutionary development of the experiences of empathy that marked the beginning of morality and art. We argue that aesthetic and moral capacities provided an important foundation for later epistemic developments.
Horne, Spencer, Montemayor, Carlos
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Emergence of wellbeing in community participation [PDF]

, 2014
This paper explores and reflects upon the literature and several mini case studies to recommend a change of focus for the linking management and development of community participants and community organisations.
George, Karen, Sice, Petia
core   +1 more source