Results 221 to 230 of about 60,683 (295)

(Re)humanizing Blackness: Integrating BlackCrit in the Mental Health Counseling of Black Clients

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT Does Black mental health matter? Historically, mental illness in the Black community has been inadequately addressed. Yet Black Americans experience more severe psychological distress than other races, and they are also more likely to experience poor outcomes in counseling.
Demetrius Cofield
wiley   +1 more source

Platelet transfusion in end-of-life adult care. [PDF]

Hematol Transfus Cell Ther
Cibele D, Trigo F, Barbosa M, Almeida J, Paiva JA, Gonçalves E, Brito J, Teixeira J, Araújo F.   +8 more
europepmc   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Dupilumab as an effective therapy for eosinophilic esophagitis in pediatric patients weighing less than 15 kilograms

JPGN Reports, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is a type 2 cytokine‐mediated chronic inflammatory condition leading to esophageal dysfunction. Dupilumab blocks IL‐4 and IL‐13 signaling, which are key inflammatory mediators in EoE and other allergic disorders.
Sindhura Kasturi, Tanaz Danialifar, Thirumazhisai Gunasekaran, Nick Shillingford, Paul Zamiara, Vrinda Bhardwaj, Melinda Braskett   +6 more
wiley   +1 more source

SITA: Predicting site-specific immunogenicity for therapeutic antibodies. [PDF]

J Pharm Anal
Cun Y, Ding H, Mao T, Wang Y, Wang C, Li J, Li Z, Hu M, Cao Z, Qiu T.   +9 more
europepmc   +1 more source

Brazilian Society of Surgical Oncology: Guidelines and Consensus Statement for Palliative Surgery in Oncology

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objective Palliative surgery in oncology aims to relieve symptoms, improve quality of life, and respect patient autonomy in advanced cancer. This study aimed to develop evidence‐based recommendations for safely indicating and performing palliative surgeries in Brazil, considering clinical, ethical, and multidisciplinary aspects.
Audrey Cabral Ferreira de Oliveira, Jordana Henz Hammes, Isabela Maria Alves de Almeida Oliva, Lara Andrade Mendes Mangieri, Ronald Enrique Delgado Bocanegra, Marcos Gonçalves Adriano Junior, Ana Caroline Fonseca Alves, Eliel Oliveira de Araujo, Jairo Cerqueira de Almeida Teixeira, Patricia Isabel Bahia Mendes Freire, Larissa de Jesus Almeida, Raquel Lacerda Dantas de Farias, Heládio Feitosa e Castro Neto, Alexandre Ferreira Oliveira, Reitan Ribeiro, Rodrigo Nascimento Pinheiro   +15 more
wiley   +1 more source

Nanobodies: From Discovery to AI-Driven Design. [PDF]

Biology (Basel)
Zhu H, Ding Y.
europepmc   +1 more source

Characteristics and Clinical Outcomes of Patients With Hidradenitis Suppurativa (HS) Treated With Bimekizumab: A Canadian Retrospective Chart Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterised by painful nodules, abscesses, and draining and non‐draining tunnels. Currently, there are two biologics approved in Canada for the treatment of moderate‐to‐severe HS, adalimumab (anti‐TNF) and secukinumab (anti‐IL‐17A).
Irina Turchin, Tracey Brown‐Maher, Hélène Veillette, David O. Croitoru, Kyle Cullingham   +4 more
wiley   +1 more source

Computational Prediction of Single-Domain Immunoglobulin Aggregation Propensities Facilitates Discovery and Humanization of Recombinant Nanobodies. [PDF]

Antibodies (Basel)
Geyer FK, Borbeck J, Palka W, Zhou X, Takimoto J, Rabinovich B, Reifenhäuser B, Friedrich K, Kolmar H.   +8 more
europepmc   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source