Results 1 to 10 of about 13,568 (117)

Delivery technologies for human vaccines [PDF]

British Medical Bulletin, 2002
There is currently intense research activity aimed at the development of new delivery systems for vaccines. The goal is to identify optimal methods for presenting target antigens to the immune system in a manner that will elicit immune responses appropriate for protection against, or treatment of, a specific disease.
Philippe, Moingeon, Charles, de Taisne, Jeffrey, Almond   +2 more
openaire   +2 more sources

Global Delivery of Human Papillomavirus Vaccines [PDF]

Pediatric Clinics of North America, 2016
Worldwide, cervical cancer is the fourth most common cancer among women. Human papillomavirus (HPV) vaccination, if broadly implemented, has the potential to significantly reduce global rates of morbidity and mortality associated with cervical and other HPV-related cancers. More than 100 countries around the world have licensed HPV vaccines.
Wigle, Jannah, Fontenot, Holly B., Zimet, Gregory D.   +2 more
openaire   +2 more sources

RNA Aptamer Delivery through Intact Human Skin [PDF]

Journal of Investigative Dermatology, 2018
It is generally recognized that only relatively small molecular weight (typically < ∼ 500 Da) drugs can effectively permeate through intact stratum corneum. Here, we challenge this orthodoxy using a 62-nucleotide (molecular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-23 cytokine, with picomolar activity.
Jon D. Lenn, Jessica Neil, Christine Donahue, Kellie Demock, Caitlin Vestal Tibbetts, Javier Cote-Sierra, Susan H. Smith, David Rubenstein, Jean-Philippe Therrien, P. Shannon Pendergrast, Jason Killough, Marc B. Brown, Adrian C. Williams   +12 more
openaire   +2 more sources

Intracoronary Heparin Delivery in Humans [PDF]

Circulation, 1995
Background Inefficacy of systemic drug administration for restenosis prevention may partially relate to insufficient local drug concentration. This study aimed to evaluate the acute feasibility and long-term outcome of using an infusion-perfusion coil balloon, Dispatch. Methods and Results
Camenzind, Edoardo, Kint, Peter Paul, Di Mario, Carlo, Ligthart, Jürgen, Van Der Giessen, Wim, Boersma, Eric, Serruys, Patrick W.   +6 more
openaire   +2 more sources

Reimagining career guidance: towards a pluralistic perspective [PDF]

, 2014
Difficulties concerning the identified mis-match between supply and demand sides of the labour market are discussed. The variability of career guidance services for young people across Europe is illustrated together with policy initiatives in some cases ...
CM Velte, H Glauert, NN Sørensen, NR Garcia, WJ Zhu, WJ Zhu, WZ Shen, WZ Shen   +7 more
core   +3 more sources

The peacebuilding potential of healthcare training programs. [PDF]

, 2016
Global health professionals regularly conduct healthcare trainings, such as first aid courses, in disadvantaged communities across the world. Many of these communities lack healthcare infrastructure because of war and political conflict. The authors draw
Katona, Lindsay B, Ratner, Kyle G
core   +1 more source

Delivery of Active AKT1 to Human Cells

Cells, 2022
Protein kinase B (AKT1) is a serine/threonine kinase and central transducer of cell survival pathways. Typical approaches to study AKT1 biology in cells rely on growth factor or insulin stimulation that activates AKT1 via phosphorylation at two key regulatory sites (Thr308, Ser473), yet cell stimulation also activates many other kinases.
Tarana Siddika, Nileeka Balasuriya, Mallory I. Frederick, Peter Rozik, Ilka U. Heinemann, Patrick O’Donoghue   +5 more
openaire   +3 more sources

Peptide nucleic acid delivery to human mitochondria [PDF]

Gene Therapy, 1999
Peptide nucleic acids (PNAs) are synthetic polynucleobase molecules, which bind to DNA and RNA with high affinity and specificity. Although PNAs have enormous potential as anti-sense agents, the success of PNA-mediated gene therapy will require efficient cellular uptake and sub-cellular trafficking. At present these mechanisms are poorly understood. To
Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN   +5 more
openaire   +3 more sources

Treating patients as persons : a capabilities approach to support delivery of person-centered care [PDF]

, 2013
Peer reviewedPublisher ...
Beauchamp T. L., Coulter A., Flannagan O., Gerteis M., Goodrich J., Ian S. Watt, Institute of Medicine, International Alliance of Patients’ Organizations, Kant I., Mackenzie C., McCormack B. J., McLeod C., Meyers D. T., Mezzich J., Mol A., NHS Scotland, Robeyns I., Ruger J. P., Sen A., Stewart M., Venkatapuram S., Vikki A. Entwistle, World Health Organization   +22 more
core   +1 more source

Human rights-based service delivery

Regions and Cohesion, 2018
English Abstract:This article examines the extent to which National Human Rights Institutions (NHRIs) in Ghana and Uganda contribute to the strengthening of democracy and sustainable development in those countries. A human rights-based approach is used to investigate human rights violations, marginalization, exclusions, and discrimination against ...
Richard Iroanya, Patrick Dzimiri, Edith Phaswana   +2 more
openaire   +1 more source