Results 61 to 70 of about 1,667 (307)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Parto domiciliar planejado: resultados maternos e neonatais Parto domiciliario planificado: resultados maternos y neonatales Planned homebirth: maternal and neonatal outcomes

Revista de Enfermagem Referência, 2010
A hospitalização de todas as parturientes, em nome da segurança e bem-estar da mãe e bebê, introduziu uma assistência mecânica, impessoal e intervencionista no parto, fazendo ressurgir o parto em domicílio.
Priscila Maria Colacioppo, Márcia Duarte Koiffman, Maria Luiza Gonzalez Riesco, Camilla Alexsandra Schneck, Ruth Hitomi Osava   +4 more
doaj  

Birth delivery assisted by nurse-midwife: perspectives and controversies [PDF]

Revista Brasileira em Promoção da Saúde, 2010
Objectives: To present the conflicts in birth deliveries assisted by nurse midwife and propose ways to minimize them. Methods: We researched the historical evolution of childbirth and the actions that were necessary for the training of professionals ...
Selma Aparecida Lagrosa Garcia, Umberto Gazi Lippi, Sidney Antonio Lagrosa Garcia   +2 more
doaj  

Obstetric violence for professionals who assist in childbirth

Revista Brasileira de Saúde Materno Infantil, 2023
Objectives: to know the perception of obstetric violence for professionals who assist in labor and delivery. Methods: the research was qualitative. Research participants were 22 professionals providing or assisting women during labor and delivery.
Angélica de Cássia Bitencourt, Samanta Luzia de Oliveira, Giseli Mendes Rennó   +2 more
doaj   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Scientific evidence about the contributions of the birth plan in obstetric care

, 2022
To analyze the scientific evidence on the contributions of the birth plan to obstetric care. Method: This is an integrative review, which used controlled descriptors: prenatal care, obstetric nursing and humanized delivery in Portuguese and Prenatal care,
Garcia, Sherry Leyane Nunes
core   +1 more source

TikTok and the changing landscape of therapeutic digital spaces of care [PDF]

, 2023
The COVID-19 pandemic increased the prevalence of mental health issues across the U.S. While therapists have been able to shift to telehealth delivery of mental healthcare, there has been a recent increase in the number of therapists on social media ...
Green, James
core   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Doulas como gatilho de tensões entre modelos de assistência obstétrica: o olhar dos profissionais envolvidos

Saúde em Debate
RESUMO Este artigo analisa a percepção dos profissionais de saúde da maior maternidade do estado da Paraíba acerca da inserção das doulas no processo de cuidado. Trata-se de estudo qualitativo, com 24 profissionais de saúde, cujo instrumento de coleta de
Thuany Bento Herculano, Juliana Sampaio, Marita de Almeida Assis Brilhante, Murillo Bruno Braz Barbosa   +3 more
doaj   +1 more source