Results 71 to 80 of about 1,306,169 (311)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Doulas como gatilho de tensões entre modelos de assistência obstétrica: o olhar dos profissionais envolvidos

Saúde em Debate
RESUMO Este artigo analisa a percepção dos profissionais de saúde da maior maternidade do estado da Paraíba acerca da inserção das doulas no processo de cuidado. Trata-se de estudo qualitativo, com 24 profissionais de saúde, cujo instrumento de coleta de
Thuany Bento Herculano, Juliana Sampaio, Marita de Almeida Assis Brilhante, Murillo Bruno Braz Barbosa   +3 more
doaj   +1 more source

Factors associated with low Apgar in newborns in birth center [PDF]

Revista Brasileira de Enfermagem, 2019
Objective: to analyze factors associated with Apgar of 5 minutes less than 7 of newborns of women selected for care at the Center for Normal Birth (ANC).
Nágela Cristine Pinheiro Santos, Sibylle Emilie Vogt, Elysângela Dittz Duarte, Adriano Marçal Pimenta, Lélia Maria Madeira, Mery Natali Silva Abreu   +5 more
doaj   +3 more sources

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

O PARTO HUMANIZADO E O SEU IMPACTO NA ASSISTÊNCIA A SAÚDE

Revista Educação em Saúde, 2015
Objective: Analysis over the humanized process of birth and it’s vicissitudes that approach both physiological and psychosocial aspects and also the technochratic specifications of it’s operation.
Laiane Pereira Barros, Chrissia Lorrany Tocchio de Souza, Leôncio de Farias Gonçalves, Letícia Noronha Gonzaga, Thaís de Andrade Paula, Andreia Moreira da Silva   +5 more
doaj  

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Childbirth and birth assistance: a quantitative study

Online Brazilian Journal of Nursing, 2007
This research, of quantitative nature, aimed to characterize the assistance offered to the binomial mother-baby in the childbirth and birth and to discuss if this assistance minimizes the risks to maternal and newborn health.
Sonia Mara Faria Simões, Deborah Valadão Jesus, Juliana Siqueira Boechat   +2 more
doaj  

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Beginning the Process of Humanizing Online Learning: Two Teachers' Experiences

, 2016
This chapter considers two autoethnographic case studies as two teachers report on their journey towards making online learning more authentic, personal and humanized.
Kilgour, Peter W., Reynaud, Emanuela, Reynaud, Daniel   +2 more
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