Results 221 to 230 of about 811,080 (260)

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

A Mimic of Metastatic Malignancy: Dietary Supplement-Associated Drug-Induced Lung Injury Presenting as Multiple Pulmonary Nodules With an Acute Fibrinous and Organizing Pneumonia Pattern. [PDF]

Respirol Case Rep
Goto Y, Nakamura Y, Yazawa N, Natsume K, Tsukada N, Tsukada A, Yoshida N, Nomura Y, Kawabe A, Arakawa H, Takemasa A, Ishida K, Shimizu Y, Niho S.   +13 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Effect of Heat and Moisture Exchanger vs Heated Humidifier on Ventilator-related Adverse Events in Children: A Pilot Randomized Controlled Trial. [PDF]

Indian J Crit Care Med
Palanisamy S, Sreevilasan SK, Venkatesh L, Jose D, Gowtham BC, Parameswaran N.   +5 more
europepmc   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Temperature and Humidity During Different Neonatal Respiratory Support Modes: An In-Vitro Performance of Four Heated Humidifiers. [PDF]

Pediatr Pulmonol
Zannin E, Rigotti C, Robbiani S, Dellacà RL, Ventura ML.   +4 more
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Atypical Legionella pneumophila encephalopathy lacking respiratory symptoms and radiographic lesions: A Case Report. [PDF]

Front Med (Lausanne)
Yan W, Wang X, Shi K, Wang L.
europepmc   +1 more source

A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications. [PDF]

Crit Care
Rezoagli E, Nova A, Carteaux G, Giani M, Grieco DL, Pettenuzzo T, Lucchini A, Navalesi P, Antonelli M, Foti G, Bellani G, Piquilloud L.   +11 more
europepmc   +1 more source

The Association of Microplastics in Peripheral Blood and Pulmonary Disease: A Pilot Study. [PDF]

J Xenobiot
Helgeson SA, Alaws H, Ibrahim MI, Lee AS, Vlecken DHW, Baig HZ.   +5 more
europepmc   +1 more source