Results 111 to 120 of about 15,911 (332)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Comparison of Active and Passive Humidifiers on Mechanical Ventilation
Türk Yoğun Bakim Derneği Dergisi, 2010 Objective: To research the effectiveness on humidifying, respiratory mechanics, bacterial colonization and infection rates of continuous usage for 96 hours of active and passive humidifiers which are used for heating and moisturizing the inspired gases ...
H. Dilek Mersin Özcanoğlu +4 more
doaj
Moisture transport processes and control of relative humidity in refrigerated facilities : a thesis presented in partial fulfilment of the requirements for the degree of Master of Engineering at Massey University, Palmerston North, New Zealand [PDF]
, 2007 Increasingly air relative humidity (RH) is becoming an important design and operational variable for refrigerated facilities. An integrated dynamic model of the main heat and moisture transfer mechanism in a refrigerated facility was developed.
Sujau, Maumoon
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Condensation of humidified air in the inflation line of a polyurethane cuff precludes correct continuous pressure monitoring during mechanical ventilation [PDF]
, 2014 Herbert Spapen +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
MUCOCILIARY TRANSPORT WITH AND WITHOUT HUMIDIFICATION IN HIGH FREQUENCY VENTILATION [PDF]
, 1982 Miroslav Klain, U. Nordin, H Keszler
openalex +1 more source