Results 51 to 60 of about 30,734 (291)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Preliminary experimental and numerical analysis of a silica gel packed bed humidification system [PDF]

E3S Web of Conferences, 2019
In this research, an innovative air humidification system based on two packed beds made of silica gel spherical particles is developed. Each bed is alternatively crossed by two airflows (regeneration and process).
Cazzaniga Edoardo, Colombo Luigi, De Antonellis Stefano   +2 more
doaj   +1 more source

Study on the Heat and Mass Transfer Characteristics of Humidifiers in Humidification–Dehumidification Desalination Systems

Energies, 2023
The humidifier plays a key role in a humidification–dehumidification (HDH) desalination system; it directly affects both the freshwater production efficiency and energy consumption ratio of the system.
Qundong Zhu, Weidong Wu, Yan Ren, Fengxian Wang, Yipeng Han   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The use of the Excellence of Google Assistant for Smart Room Monitoring and Control

Sistemasi: Jurnal Sistem Informasi, 2023
The development of technology in modern times is increasingly sophisticated, so as to create a tool that facilitates human work in operating these electronic goods.
Riska Rahma Ramadhani Nasution, Suroso Suroso, Eka Susanti   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Ultrasonic humidifier lung as a mimic of COVID‐19

Respirology Case Reports, 2021
Chest computed tomography (CT) has been used to complement coronavirus disease 2019 (COVID‐19) diagnosis due to its high sensitivity. However, owing to the low specificity of CT findings, differential diagnosis is essential.
Shosei Ro, Ryosuke Imai, Atsushi Kitamura, Torahiko Jinta, Naoki Nishimura   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Continuous Positive Airway Pressure: Is it a route for infection in those with Obstructive Sleep Apnoea? [PDF]

Sleep Science
Introduction: Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about the prevalence of respiratory infections and microbial colonization in these patients.
Liam Mercieca, Richard Pullicino, Kyra Camilleri, Rodianne Abela, Sean Apap Mangion, Julian Cassar, Matthew Zammit, Christine Gatt, Christopher Deguara, Christopher Barbara, Peter Fsadni, Stephen Montefort   +11 more
doaj   +1 more source