Results 91 to 99 of about 99 (99)

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, EarlyView.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system

The FEBS Journal, Volume 292, Issue 6, Page 1316-1329, March 2025.
This work investigates the archaeome, an essential segment of the human microbiome, focusing on its relationship with the immune system. Here, we outline the types of archaea across different body areas and underscore possible links to health issues, such as obesity and specific cancers.
Torben Kuehnast, Christina Kumpitsch, Rokhsareh Mohammadzadeh, Thomas Weichhart, Christine Moissl‐Eichinger, Holger Heine   +5 more
wiley   +1 more source

Obesity and the gut microbiota: implications of neuroendocrine and immune signaling

The FEBS Journal, Volume 292, Issue 6, Page 1397-1420, March 2025.
An unhealthy diet impairs the symbiotic relationship between the gut microbiota and the host, contributing to obesity. At the intestinal level, identification of host–microbe events essential for proper neuroendocrine/immune signaling is key to the development of microbiome‐based strategies to promote metabolic health in obesity (probiotics ...
Marina Romaní‐Pérez, Rebeca Líebana‐García, Alejandra Flor‐Duro, Daniel Bonillo‐Jiménez, Clara Bullich‐Vilarrubias, Marta Olivares, Yolanda Sanz   +6 more
wiley   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

After second year male European Starlings (Sturnus vulgaris) do not signal age through repertoire size or song bout length over a 1‐year period

Ibis, Volume 167, Issue 2, Page 575-582, April 2025.
In many passerine species, male song functions as an honest signal of male quality. Male age is one of these qualities, yielding benefits that are direct (e.g. breeding experience) and/or indirect (e.g. viability and good genes). Male European Starlings Sturnus vulgaris are open‐ended learners with long and complex songs that add songs to their ...
Maheshi E. Dharmasiri, Colleen A. Barber, Andrew G. Horn   +2 more
wiley   +1 more source

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

The gut‐microbiota‐brain axis: Focus on gut steroids

Journal of Neuroendocrinology, EarlyView.
Abstract There are over 1000 varieties of steroids that have been reported in nature, including the endogenous sex steroid hormones (i.e., progesterone, testosterone, and 17β‐estradiol) and corticosteroids which are mainly synthesized by gonads and adrenals, respectively.
Silvia Diviccaro, Silvia Giatti, Lucia Cioffi, Gabriela Chrostek, Roberto Cosimo Melcangi   +4 more
wiley   +1 more source