Results 101 to 110 of about 288,409 (327)

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells [PDF]

, 2002
Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells.
Baltimore, David, Gerondakis, Steve, Grumont, Raelene J., Gugasyan, Raffi, Metcalf, Donald, Pohl, Thomas, Sha, William, Strasser, Andreas, Tarlinton, David   +8 more
core  

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

, 2016
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the ...
Ada W.C. Yan, Antia, Badovinac, Barber, Beauchemin, Blattman, Bocharov, Bodewes, Boianelli, Boon, Bortnick, Braciale, Brown, Brown, Bui, Cao, Carolan, Carpenter, Chao, Christensen, Crowe, Davenport, De Boer, Dobrovolny, Epstein, Faroudi, Grayson, Grebe, Greenbaum, Hancioglu, Handel, Hou, Iwasaki, James M. McCaw, Jameson, Jane M. Heffernan, Jodie McVernon, Kaech, Kaech, Karen L. Laurie, Kees, Komadina, Kreijtz, Kris, Kylie M. Quinn, Laurie, Laurie, Lee, Lehmann-Grube, Luciani, Luckheeram, Marchuk, Martin, McElhaney, McMichael, Mehlhop-Williams, Miao, Miao, Murali-Krishna, Nicole L. La Gruta, Nowak, Pawelek, Pengxing Cao, Petrie, Quinn, Rammensee, Selin, Shin, Smith, Smith, Smith, Sridhar, Steel, Sze, Tanchot, Terajima, Tscharke, van Stipdonk, Veiga-Fernandes, Veiga-Fernandes, Wells, Wherry, Wirth, Wodarz, Wodarz, Yan, Yap, Yewdell, Yewdell, Zarnitsyna, Zehn   +90 more
core   +1 more source

Wise Blood: The Principle of Overcoming in Disease and Immunity (Part 1) [PDF]

, 2020
The immune system is an intelligently made system designed for interaction with microbes even in a perfect world; it is more than a defense. However, in a post-fall world, it is primarily a body’s defense system.
Gillen, Alan L., Huy, Keoprommony
core   +1 more source

Various reagent kits for comparatively analyzed effectiveness of humoral immune response after vaccination “Sputnik V"

, 2023
С. П. Казаков, D. V. Reshetnyak, Natalia Davydova, O.A. Efimushkina, Stanislav B. Putkov   +4 more
openalex   +2 more sources

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Behavior of natural and humoral immunity in hypertension

Acta Médica del Centro, 2013
The changes that occur in response to stress are divided into “central adaptations” and “peripheral adaptations”. Within the latter there are the changes in the cardiovascular system (increased pulse and blood pressure), which are not sufficient in the ...
Lay Salazar Torres, Leticia Bequer Mendoza, Tahiry Gómez Hernández, Lutgarda Pérez de Alejo Rodríguez, Francisco Acosta de Armas   +4 more
doaj  

Humoral immunity in Hansen's Disease

São Paulo Medical Journal
For many years immune response in leprosy has been studied. Since 1960 several reports dealing with humoral immunity have been described in the literature. Different autoantibody rates occur in leprosy.
Waldenise Cossermelli-Messina, Wilson Cossermelli   +1 more
doaj   +1 more source

Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Journal of Immunology Research, 2015
Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG) is the only available vaccine. However, BCG has limited applications, and a more effective vaccine is needed. Cellular mediated immunity (CMI) is thought to be the
Mamiko Niki, Maho Suzukawa, Shunsuke Akashi, Hideaki Nagai, Ken Ohta, Manabu Inoue, Makoto Niki, Yukihiro Kaneko, Kozo Morimoto, Atsuyuki Kurashima, Seigo Kitada, Sohkichi Matsumoto, Koichi Suzuki, Yoshihiko Hoshino   +13 more
doaj   +1 more source

Bombardier Enables Delivery of Short-Form Bomanins in the Drosophila Toll Response. [PDF]

, 2019
Toll mediates a robust and effective innate immune response across vertebrates and invertebrates. In Drosophila melanogaster, activation of Toll by systemic infection drives the accumulation of a rich repertoire of immune effectors in hemolymph ...
Bennett, Eric J, Cohen, Lianne B, Fulzele, Amit, Lin, Samuel JH, Wasserman, Steven A   +4 more
core