Results 81 to 90 of about 99 (99)

p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts

Cancer Science, EarlyView.
TP53 deficiency in colon cancer cells suppresses Meflin expression in fibroblasts and promotes fibroblast‐mediated tumor growth. Suppression of Meflin expression could transform normal fibroblasts into ones exhibiting a CAF‐like phenotype, promoting colon cancer cell growth.
Eiji Kimura, Yoshito Hayashi, Kentaro Nakagawa, Hirotsugu Saiki, Minoru Kato, Ryotaro Uema, Takanori Inoue, Takeo Yoshihara, Akihiko Sakatani, Hiromu Fukuda, Ayaka Tajiri, Yujiro Adachi, Kazuhiro Murai, Shunsuke Yoshii, Yoshiki Tsujii, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara   +17 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The Complex Nomenclature of Allergic Diseases and Hypersensitivity Reactions: An Addendum to the EAACI Position Paper

Allergy, Volume 80, Issue 4, Page 1162-1165, April 2025.
Andrea Szegedi, Zsolt I. Komlósi, Anikó Kapitány, Zsuzsanna Bata‐Csörgő, Gábor Koncz, Attila Bácsi   +5 more
wiley   +1 more source

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral CAR‐NK Cell Engineering

Cell Proliferation, Volume 58, Issue 4, April 2025.
This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu   +18 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

LL‐37 Inhibits TMPRSS2‐Mediated S2' Site Cleavage and SARS‐CoV‐2 Infection but Not Omicron Variants

Cell Proliferation, EarlyView.
Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Zhenfei Bi, Wenyan Ren, Hao Zeng, Yuanyuan Zhou, Jian Liu, Zimin Chen, Xindan Zhang, Xuemei He, Guangwen Lu, Yuquan Wei, Xiawei Wei   +10 more
wiley   +1 more source

Research in practice: Immune checkpoint inhibitor related autoimmune bullous dermatosis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 4, Page 441-445, April 2025.
Summary Immune checkpoint receptors and ligands such as cytotoxic T lymphocyte antigen‐4 (CTLA‐4), programmed death‐1 (PD‐1) and ligand‐1 (PD‐L1) are widely expressed on immune and non‐immune cells and fine tune the activation level of immune cells, thus, enabling, preventing, or terminating immune responses.
Jasper N. Pruessmann, Wiebke Pruessmann, Christian D. Sadik   +2 more
wiley   +1 more source