Results 1 to 10 of about 28,868 (258)

Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

Frontiers in Physiology, 2023
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.
Fanny L. Lemarié, Shaun S. Sanders, Yen Nguyen, Dale D. O. Martin, Michael R. Hayden   +4 more
doaj   +2 more sources

Huntingtin and the Synapse [PDF]

Frontiers in Cellular Neuroscience, 2021
Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic ...
J. Barron, E. Hurley, Matthew P. Parsons
semanticscholar   +6 more sources

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.

PLoS ONE, 2019
One response of cells to growth factor stimulus involves changes in morphology driven by the actin cytoskeleton and actin associated proteins which regulate functions such as cell adhesion, motility and in neurons, synaptic plasticity.
Adelaide Tousley, Maria Iuliano, Elizabeth Weisman, Ellen Sapp, Heather Richardson, Petr Vodicka, Jonathan Alexander, Neil Aronin, Marian DiFiglia, Kimberly B Kegel-Gleason   +9 more
doaj   +2 more sources

Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin-mediated endocytosis [PDF]

eLife
Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington’s disorder. In addition to neurons, cellular processes in non-neuronal cell types are also shown to be affected.
Surya Bansi Singh, Shatruhan Singh Rajput, Aditya Sharma, Sujal Kataria, Priyanka Dutta, Vaishnavi Ananthanarayanan, Amitabha Nandi, Shivprasad Patil, Amitabha Majumdar, Deepa Subramanyam   +9 more
doaj   +2 more sources

Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease

Disease Models & Mechanisms
Jocelynn R. Pearl, Amol C. Shetty, Jeffrey P. Cantle, Dani E. Bergey, Robert M. Bragg, Sydney R. Coffey, Holly B. Kordasiewicz, Leroy E. Hood, Nathan D. Price, Seth A. Ament, Jeffrey B. Carroll   +10 more
doaj   +2 more sources

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches

Brain Communications, 2023
Huntingtin-lowering approaches that target huntingtin expression are a major focus for therapeutic intervention for Huntington’s disease. When the cytosine, adenine and guanine repeat is expanded, the huntingtin pre-mRNA is alternatively processed to ...
Edward J. Smith, K. Sathasivam, C. Landles, Georgina F Osborne, Michael A. Mason, Casandra Gomez-Paredes, Bridget A Taxy, Rebecca E Milton, Anne Ast, F. Schindler, Chuangchuang Zhang, W. Duan, E. Wanker, G. Bates   +13 more
semanticscholar   +1 more source

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Nature Communications, 2021
The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal ...
M. Eshraghi, P. Karunadharma, Juliana Blin, N. Shahani, Emiliano P. Ricci, Audrey M. Michel, Nicolai T. Urban, Nicole Galli, Manish Sharma, U. N. Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, S. Subramaniam   +12 more
semanticscholar   +1 more source

Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia. [PDF]

PLoS ONE, 2014
Patients with Huntington's disease exhibit memory and cognitive deficits many years before manifesting motor disturbances. Similarly, several studies have shown that deficits in long-term synaptic plasticity, a cellular basis of memory formation and ...
Yun-Beom Choi, Beena M Kadakkuzha, Xin-An Liu, Komolitdin Akhmedov, Eric R Kandel, Sathyanarayanan V Puthanveettil   +5 more
doaj   +1 more source

Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms

Acta Medica Lituanica, 2021
Background: In Huntington’s disease psychiatric symptoms may manifest prior to motor dysfunction. Such symptoms negatively impact people’s quality of life and can worsen the course of the primary disease.
Adelė Butėnaitė, Robertas Strumila, Aistė Lengvenytė, Indrė Kotryna Pakutkaitė, Aušra Morkūnienė, Aušra Matulevičienė, Edgaras Dlugauskas, Algirdas Utkus   +7 more
doaj   +1 more source

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Frontiers in Molecular Biosciences, 2021
Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of the Huntingtin protein (Htt) have been shown to inhibit the aggregation and attenuate the toxicity of mutant Htt proteins in vitro and in various models of Huntington’s ...
Anass Chiki, Zhidian Zhang, Zhidian Zhang, Kolla Rajasekhar, Luciano A. Abriata, Iman Rostami, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro, Hilal A. Lashuel   +10 more
doaj   +1 more source