Results 51 to 60 of about 37,460 (168)

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance [PDF]

The FASEB Journal, 2017
ABSTRACTHuntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum leading to changes in behavior and loss of motor coordination. It is caused by an expansion in the polyglutamine repeat at the N-terminus of huntingtin (HTT) that leads to aggregation of mutant HTT.
Martin, D.D.O., Schmidt, M. E., Nguyen, Y. T., Lazic, N., Hayden, M. R.   +4 more
openaire   +4 more sources

siRNA screen identifies QPCT as a druggable target for Huntington's disease. [PDF]

, 2015
Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT).
Andreini, Matteo, Caradonna, Nicola P., Caramelli, Chiara, Caricasole, Andrea, Dami, Teresa Ed, Diamanti, Daniela, Fleming, Angeleen, Gonzalez-Couto, Eduardo, Hannus, Michael, Heitz, Freddy, Imarisio, Sara, Jimenez-Sanchez, Maria, Lam, Wun, Lazzeroni, Giulia, Marconi, Guido, Massai, Luisa, Menzies, Fiona, Nencini, Arianna, O?Kane, Cahir J., Pollio, Giuseppe, Porcari, Valentina, Rubinsztein, David C., S?nnichsen, Birte, Sardone, Gian Luca, Satagopam, Venkata P., Scali, Carla, Schneider, Reinhard, Tarditi, Alessia, Xu, Catherine   +28 more
core   +5 more sources

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case–Control Study

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Thermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention. Objectives We aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy ...
Lucía Simón‐Vicente, Jéssica Rivadeneyra‐Posadas, María Soto‐Célix, Javier Raya‐González, Alejandro Rodríguez‐Fernández, Daniel Castillo‐Alvira, Fernando Vázquez, Esther Cubo   +7 more
wiley   +1 more source

PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]

, 2012
Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M, Frautschy, Sally A, Ma, Qiu-Lan, Yang, Fusheng   +3 more
core   +1 more source

Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (mHTT), comprising 35 manifest (mHD) and 14 pre‐manifest (PreHD), and 35 healthy controls (HC) were recruited in this study.
Jin‐Hui Yin, Ling‐Xiao Cao, Ya‐Ou Liu, Yue Huang   +3 more
wiley   +1 more source