Results 221 to 230 of about 37,064 (267)

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates. [PDF]

J Biol Chem
Lugo J, Xu H, Chen J, Khoshnan A, Langen R.   +4 more
europepmc   +1 more source

Surface-Engineered Precision Nano-Systems for Targeted Treatment of Huntington's Disease: A Review of Recent Advancements. [PDF]

Int J Nanomedicine
Zhang J, Nie L, Ma J, Wang X.
europepmc   +1 more source

Mutant huntingtin expression in somatostatin-positive interneurons contributes to neurophysiological and behavioral phenotypes in BACHD mice. [PDF]

Dis Model Mech
Fowler JA, Scarduzio M, Pool C, Mahan CD, Gray M.   +4 more
europepmc   +1 more source

Perturbation of multiprotein complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins. [PDF]

NPJ Aging
Rai M, Baddeley HJE, Chuang CL, Platt A, Curley M, Finkelstein D, Demontis F.   +6 more
europepmc   +1 more source

Huntingtin in the amygdaloid basolateral complex is correlated with Vonsattel staging in Huntington's disease. [PDF]

Brain Commun
Sanchez-Migallon P, Flores-Cuadrado A, Villanueva-Anguita P, Rabano A, Vaamonde J, Saiz-Sanchez D, Mohedano-Moriano A, Astillero-Lopez V, Soriano-Herrador C, Martinez-Marcos A, Ubeda-Banon I.   +10 more
europepmc   +1 more source

In Vivo PET Imaging of [¹⁸F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease. [PDF]

J Nucl Med
Zajicek F, Elvas F, Miranda A, Akkermans J, Verhaeghe J, Dominguez C, Doot R, Khetarpal V, Bard J, Liu L, Staelens S, Bertoglio D.   +11 more
europepmc   +1 more source

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Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

Cellular and Molecular Life Sciences, 2022
Huntingtin-associated protein 1 (HAP1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mHTT), which causes Huntington disease. However, the expression patterns of Hap1 and Htt in the rodent brain are not correlated.
Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua Li   +15 more
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Glassy dynamics in mutant huntingtin proteins

The Journal of Chemical Physics, 2018
Causative to the neurodegenerative Huntington’s disease (HD), a mutational huntingtin (HTT) protein consists of an unusual expansion on the poly-glutamine (polyQ) region in the first exon (exon-1) domain. Despite its significance on HD progression, the structural role of the exon-1 with the polyQ region is still elusive.
Hongsuk Kang, Binquan Luan, Ruhong Zhou
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Huntington Disease and the Huntingtin Protein

2012
Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive personality changes, movement disorder, and dementia and can develop in children and adults.
Zhiqiang, Zheng, Marc I, Diamond
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