Results 1 to 10 of about 40,748 (225)

Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin-mediated endocytosis

eLife
Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington’s disorder. In addition to neurons, cellular processes in non-neuronal cell types are also shown to be affected.
Surya Bansi Singh, Shatruhan Singh Rajput, Aditya Sharma, Sujal Kataria, Priyanka Dutta, Vaishnavi Ananthanarayanan, Amitabha Nandi, Shivprasad Patil, Amitabha Majumdar, Deepa Subramanyam   +9 more
doaj   +1 more source

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

BMC Neuroscience, 2002
Background Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function ...
Gusella James F, Takano Hiroki
doaj   +1 more source

Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration. [PDF]

, 2019
Current approaches for dynamic profiling of single cells rely on dissociated cultures, which lack important biological features existing in tissues. Organotypic slice cultures preserve aspects of structural and synaptic organisation within the brain and ...
Barch, Mariya, Campioni, Matthew, Epstein, Irina, Finkbeiner, Steven, Javaherian, Ashkan, Linsley, Jeremy W, Mount, Elliot, Nowakowski, Tomasz J, Oza, Viral, Samsi, Siddharth, Schmunk, Galina, Tripathi, Atmiyata   +11 more
core  

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]

, 2019
Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis, Chan, C Savio, Chen, Yu, Day, Michelle, Guzman, Jaime N, Ilijic, Ema, Kaplitt, Michael, Kondapalli, Jyothisri, Kress, Geraldine J, Melendez, Alexandria E, Plotkin, Joshua L, Surmeier, D James, Wokosin, David L, Xie, Zhong   +13 more
core   +1 more source

Localization and function of the Drosophila huntingtin protein [PDF]

, 2007
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007."September 3, 2007."Includes bibliographical references (p. 34-40).Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expansion of a ...
Mediatore, James D
core  

Preserved VPS13A distribution and expression in Huntington’s disease: divergent mechanisms of action for similar movement disorders?

Frontiers in Neuroscience
VPS13A disease and Huntington’s disease (HD) are two basal ganglia disorders that may be difficult to distinguish clinically because they have similar symptoms, neuropathological features, and cellular dysfunctions with selective degeneration of the ...
Esther García-García, Esther García-García, Esther García-García, Maria Carreras-Caballé, Maria Carreras-Caballé, Albert Coll-Manzano, Alba Ramón-Lainez, Alba Ramón-Lainez, Alba Ramón-Lainez, Gisela Besa-Selva, Gisela Besa-Selva, Gisela Besa-Selva, Esther Pérez-Navarro, Esther Pérez-Navarro, Esther Pérez-Navarro, Cristina Malagelada, Cristina Malagelada, Cristina Malagelada, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Mercè Masana, Mercè Masana, Mercè Masana, Manuel J. Rodríguez, Manuel J. Rodríguez, Manuel J. Rodríguez   +27 more
doaj   +1 more source

Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy

Autophagy Reports
Neurons, as post–mitotic and long–lived cells, rely heavily on autophagy to maintain cellular homoeostasis and ensure proper function. Huntingtin (HTT), a protein central to Huntington’s disease (HD), has emerged as a putative multifunctional regulator ...
Thomas J. Krzystek, Shermali Gunawardena
doaj   +1 more source

Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells [PDF]

, 2019
学位記番号 ...
Mohara, Miho, モハラ, ミホ, 茂原, 美穂   +2 more
core  

The kabod Spring 2016 [PDF]

, 2016
Completed issue of article publications for Spring ...

core   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source