Results 21 to 30 of about 52,129 (204)

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease [PDF]

Scientific Reports, 2021
AbstractSalivary cortisol dysrhythmias have been reported in some, but not all studies assessing hypothalamic–pituitary–adrenal (HPA) axis function in Huntington’s disease (HD). These differences are presumed to be due to environmental influences on temporal salivary cortisol measurement. Further exploration of HPA-axis function using a more stable and
Simon M. Laws, Simon M. Laws, Tenielle Porter, Tenielle Porter, Mel Ziman, Mel Ziman, Danielle M. Bartlett, Travis Cruickshank   +7 more
openaire   +4 more sources

Preserving cortico-striatal function: deep brain stimulation in Huntington’s disease [PDF]

Frontiers in Systems Neuroscience, 2015
Huntington's disease (HD) is an incurable neurodegenerative disease characterized by the triad of chorea, cognitive dysfunction and psychiatric disturbances. Since the discovery of the HD gene, the pathogenesis has been outlined, but to date a cure has not been found.
John T. Gale, John T. Gale, Sean J. Nagel, Mayur Pandya, Darlene A. Lobel, Andre G. Machado   +5 more
openaire   +2 more sources

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease [PDF]

, 2015
ACKNOWLEDGEMENTS We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America and the Huntington Study Group.
Downing, Nancy, Kim, Ji-In, Long, Jeffrey D, Miedzybrodzka, Zofia Helena, Mills, James A, Paulsen, Jane S, PREDICT-HD Investigators And Coordinators Of The Huntington Study Group, Williams, Janet K   +7 more
core   +1 more source

Risk-taking and pathological gambling behavior in Huntington’s disease [PDF]

Frontiers in Behavioral Neuroscience, 2014
Huntington's disease (HD) is a genetic, neurodegenerative disorder, which specifically affects striatal neurons of the indirect pathway, resulting in a progressive decline in muscle coordination and loss of emotional and cognitive control. Interestingly, predisposition to pathological gambling and other addictions involves disturbances in the same ...
Kalkhoven, C.E., Sennef, C., Peeters, A., Bos, R. van den   +3 more
openaire   +5 more sources

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source

Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations [PDF]

, 2016
Behavioral symptoms are an important feature of Huntington’s disease and contribute to impairment in quality of life. The Movement Disorder Society commissioned the assessment of the clinimetric properties of rating scales in Huntington’s disease in ...
Bachoud-Levi, Banaszkiewicz, Baudic, Beglinger, Beglinger, Beglinger, Blackwell, Brugger, Brusa, Burns, Callaghan, Chatterjee, Como, Craig, Craufurd, Curtis, Dale, Decruyenaere, Delmaire, Dominguez, DudokdeWit, Duff, Duijn, Duijn, Duijn, Duijn, Epping, Gargiulo, Gray, Group, Hamilton, Hamilton, Ho, Holl, Horowitz, Hubers, Jankovic, Justo, Kingma, Kloppel, Kulisevsky, Leroi, Levy, Litvan, Lucetti, Lundervold, Lundin, Marder, Mayberg, Mestre, Meyer, Moulton, Naarding, Nimmagadda, Orth, Paulsen, Paulsen, Peavy, Pflanz, Poudel, Reedeker, Reedeker, Rees, Reilmann, Rickards, Rickards, Schrag, Sitek, Sitek, Snaith, Souza, Spielberger, Sprengelmeyer, Starkstein, Stout, Tabrizi, Tippett, Vassos, Vitale, Watson, Wetzel, Wing, Wong, Yebenes, Zappacosta   +84 more
core   +1 more source

Dual tasking impairments are associated with striatal pathology in Huntington’s disease [PDF]

Annals of Clinical and Translational Neurology, 2020
AbstractBackgroundRecent findings suggest that individuals with Huntington’s disease (HD) have an impaired capacity to execute cognitive and motor tasks simultaneously, or dual task, which gradually worsens as the disease advances. The onset and neuropathological changes mediating impairments in dual tasking in individuals with HD are unclear.
Pauline Zaenker, Timothy S. Pulverenti, Danielle M. Bartlett, Johnny Lo, Timothy Rankin, Timothy Rankin, Govinda Poudel, Travis Cruickshank, Travis Cruickshank, Kirk W. Feindel, Grant Rowe, Mel Ziman, Mel Ziman, Nellie Georgiou-Karistianis, Alvaro Reyes   +14 more
openaire   +7 more sources

Regulatory mechanisms of incomplete huntingtin mRNA splicing

Nature Communications, 2018
Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.
Andreas Neueder, Anaelle A. Dumas, Agnesska C. Benjamin, Gillian P. Bates   +3 more
doaj   +1 more source

Exploring the structural relationship between interviewer and self-rated affective symptoms in Huntington’s disease [PDF]

, 2016
This study explores the structural relationship between self-report and interview measures of affect in Huntington’s disease. The findings suggest continued use of both to recognize the multidimensionality within a single common consideration of ...
Callaghan J, Dale M, Ferraldeschi M, Maltby J, REGISTRY Investigators of the European Huntington’s Disease Network, Rickards H, Ristori G., Romano S, Underwood M   +8 more
core   +1 more source