Results 41 to 50 of about 10,466,444 (219)

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity [PDF]

, 2008
Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected.
Bugg, Charles W., Dunn, Denise E., Khoshnan, Ali, Lo, Donald C., Patterson, Paul H., Southwell, Amber L.   +5 more
core   +2 more sources

Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease

Behavioural Neurology, 2016
Pain was rarely studied in Huntington’s disease (HD). We presently aimed to extend our previous study on pain pathways functions by laser evoked potentials (LEPs) to a larger cohort of early unmedicated HD patients and a small group of presymptomatic HD (
Marina de Tommaso, Giovanni Franco, Katia Ricci, Anna Montemurno, Vittorio Sciruicchio   +4 more
doaj   +1 more source

Case report: Cerebellar sparing in juvenile Huntington's disease

Frontiers in Neurology, 2023
Juvenile Huntington's disease is an early-onset variant of Huntington's disease, generally associated with large CAG repeats and distinct clinical symptoms. The role of the cerebellum in Huntington's disease has been reevaluated, based on the presence of
Bruno Lopes Santos-Lobato, Bruno Lopes Santos-Lobato, Jéssica Santos de Souza Rocha, Luciano Chaves Rocha   +3 more
doaj   +1 more source

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source

Additional file 3 of Common disease signatures from gene expression analysis in Huntingtonâ s disease human blood and brain

, 2016
Modules in blood significantly correlated with HD. This file contains the 8 modules that were identified in blood as being correlated to the HD phenotype. The file describes each module according to the most representative annotations per semantic category (biological processes, cellular component, molecular function, disease or syndrome). (DOC 16.5 kb)
Mina, Eleni, Roon-Mom, Willeke Van, Hettne, Kristina, Zwet, Erik Van, Goeman, Jelle, Neri, Christian, Hoen, Peter A.C., Mons, Barend, Roos, Marco   +8 more
openaire   +1 more source

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington’s Disease

Frontiers in Neurology, 2017
The selection of an appropriate segmentation tool is a challenge facing any researcher aiming to measure gray matter (GM) volume. Many tools have been compared, yet there is currently no method that can be recommended above all others; in particular ...
Eileanoir B. Johnson, Sarah Gregory, Hans J. Johnson, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Raymund A. Roos, Geraint Rees, Sarah J. Tabrizi, Rachael I. Scahill   +9 more
doaj   +1 more source

Additional file 1 of Common disease signatures from gene expression analysis in Huntingtonâ s disease human blood and brain

, 2016
Significantly correlated modules in brain. This file contains the modules from each brain region (caudate, BA4, BA9 and cerebellum) that were associated with the disease phenotype. The numbers (P v a l u e) indicate the correlation of each module with the disease phenotype. Green: negative correlation, red: positive correlation.
Mina, Eleni, Roon-Mom, Willeke Van, Hettne, Kristina, Zwet, Erik Van, Goeman, Jelle, Neri, Christian, Hoen, Peter A.C., Mons, Barend, Roos, Marco   +8 more
openaire   +1 more source

Test–Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study

Frontiers in Psychology, 2018
Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) across multiple domains.
Clare E. Palmer, Douglas Langbehn, Sarah J. Tabrizi, Marina Papoutsi   +3 more
doaj   +1 more source

Additional file 1: of Manifestation of Huntingtonâ s disease pathology in human induced pluripotent stem cell-derived neurons

, 2016
Figure S1. PSC lines characterization. Figure S2. HD and WT PSC derived neurons analysis. Figure S3. Nuclear indentations in HD PSC derived neurons. Figure S4. Classification of up-regulated genes in HD neurons compared to WT neurons with GOrilla tool by molecular function. Figure S5.
Nekrasov, Evgeny, Vigont, Vladimir, Klyushnikov, Sergey, Lebedeva, Olga, Vassina, Ekaterina, Bogomazova, Alexandra, Chestkov, Ilya, Semashko, Tatiana, Kiseleva, Elena, Suldina, Lyubov, Bobrovsky, Pavel, Zimina, Olga, Ryazantseva, Maria, Skopin, Anton, Illarioshkin, Sergey, Kaznacheyeva, Elena, Lagarkova, Maria, Kiselev, Sergey   +17 more
openaire   +1 more source

Additional file 1: of Unmet needs for healthcare and social support services in patients with Huntingtonâ s disease: a cross-sectional population-based study

, 2015
The Needs and Provision Complexity Scale. (PDF 102 kb)
van Walsem, Marleen, Howe, Emilie, Iversen, Kristin, Frich, Jan, Andelic, Nada   +4 more
openaire   +1 more source