Results 41 to 50 of about 4,904,701 (256)

Additional file 1 of Common disease signatures from gene expression analysis in Huntingtonâ s disease human blood and brain

, 2016
Significantly correlated modules in brain. This file contains the modules from each brain region (caudate, BA4, BA9 and cerebellum) that were associated with the disease phenotype. The numbers (P v a l u e) indicate the correlation of each module with the disease phenotype. Green: negative correlation, red: positive correlation.
Mina, Eleni, Roon-Mom, Willeke Van, Hettne, Kristina, Zwet, Erik Van, Goeman, Jelle, Neri, Christian, Hoen, Peter A.C., Mons, Barend, Roos, Marco   +8 more
openaire   +1 more source

Additional file 1 of Identify Huntingtonâ s disease associated genes based on restricted Boltzmann machine with RNA-seq data

, 2017
Supplementary Material. The detail derivation process for solving the gradients of RBMs learning is given in the Supplementary Material. (PDF 321 kb)
Jiang, Xue, Zhang, Han, Duan, Feng, Quan, Xiongwen   +3 more
openaire   +1 more source

Health-related quality of life in Huntington’s Disease patients: a comparison of proxy assessment and patient self-rating using the disease-specific Huntington’s Disease health-related quality of life questionnaire (HDQoL) [PDF]

, 2012
Huntington’s disease (HD) is a fatal, neurodegenerative disease for which there is no known cure. Proxy evaluation is relevant for HD as its manifestation might limit the ability of persons to report their health-related quality of life (HrQoL).
Gaffan, E A, Ho, Aileen K, E. A. Gaffan, Aileen K. Ho, Hocaoglu, M. B., Hocaoglu, Mevhibe B; id_orcid, Ho, Aileen K., Mevhibe B. Hocaoglu, Gaffan, Elizabeth A.   +8 more
core   +1 more source

Test–Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study

Frontiers in Psychology, 2018
Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) across multiple domains.
Clare E. Palmer, Douglas Langbehn, Sarah J. Tabrizi, Marina Papoutsi   +3 more
doaj   +1 more source

Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]

Journal of Integrative Neuroscience, 2020
Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
doaj   +1 more source

Additional file 1: of Unmet needs for healthcare and social support services in patients with Huntingtonâ s disease: a cross-sectional population-based study

, 2015
The Needs and Provision Complexity Scale. (PDF 102 kb)
van Walsem, Marleen, Howe, Emilie, Iversen, Kristin, Frich, Jan, Andelic, Nada   +4 more
openaire   +1 more source

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source

Additional file 6: Figure S2. of Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntingtonâ s disease are not reflected in mutant Huntingtin inclusion prevalence

, 2015
Analysis of the overlap of changes in gene expression in the YAC128 striatum at A. 6 months of age B. 12 months of age and C. 18 months of age compared with other HD model mouse striata and human brain. Frequency represents the fraction of the top 200 HdhQ150 expression changes that map to a particular bin of ranked data (1000 genes per bin) in the ...
Zubeyde Bayram-Weston, Stone, Timothy, Giles, Peter, Elliston, Linda, Nari Janghra, Higgs, Gemma, Holmans, Peter, Dunnett, Stephen, Brooks, Simon, Jones, Lesley   +9 more
openaire   +1 more source

22 Years of predictive testing for Huntington’s disease : the experience of the UK Huntington’s Prediction Consortium

, 2017
"22 Years of predictive testing for Huntington’s disease: the experience of the UK Huntington’s Prediction Consortium" European Journal of Human Genetics (2016) 24, 1515; doi:10.1038/ejhg.2016.81 Corrigendum: 15 September 2016 European Journal of Human ...
Quarrell, Oliver W, UK Huntington’s Disease Prediction Consortium   +1 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source