Results 51 to 60 of about 10,466,444 (219)

Basal ganglia role in learning rewarded actions and executing previously learned choices: Healthy and diseased states [PDF]

, 2020
The basal ganglia (BG) is a collection of nuclei located deep beneath the cerebral cortex that is involved in learning and selection of rewarded actions. Here, we analyzed BG mechanisms that enable these functions.
Atwood, Brady, Kuznetsov, Alexey, Mulcahy, Garrett   +2 more
core   +1 more source

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source

Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]

Journal of Integrative Neuroscience, 2020
Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
doaj   +1 more source

Additional file 1: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Additional probes used on the microarray. Probes added to the default Nimblegen library to interrogate additional rat genes (A) or as expression controls for eGFP-Htt levels (B). (PDF 34 kb)
van Hagen, Martijn, Piebes, Diewertje, de Leeuw, Wim, Vuist, Ilona, van Roon-Mom, Willeke, Moerland, Perry, Verschure, Pernette   +6 more
openaire   +1 more source

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease [PDF]

, 2015
ACKNOWLEDGEMENTS We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America and the Huntington Study Group.
Downing, Nancy, Kim, Ji-In, Long, Jeffrey D, Miedzybrodzka, Zofia Helena, Mills, James A, Paulsen, Jane S, PREDICT-HD Investigators And Coordinators Of The Huntington Study Group, Williams, Janet K   +7 more
core   +1 more source

Astrocyte molecular signatures in Huntington’s disease

Science Translational Medicine, 2019
Astrocyte gene expression is altered in mouse models of Huntington’s disease and in postmortem brain samples from patients with HD. A shared signature Huntington’s disease is a neurodegenerative disorder caused by a dominant mutation in the HTT gene ...
Blanca Díaz-Castro, Mohitkumar R. Gangwani, Xinzhu Yu, G. Coppola, B. Khakh   +4 more
semanticscholar   +1 more source

MOESM2 of The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntingtonâ s disease brain

, 2019
Additional file 2 PCA Outlier ...
Agus, Filisia, Crespo, Diego, Myers, Richard, Labadorf, Adam   +3 more
openaire   +1 more source

Additional file 7: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Expression profiles for all fourteen clusters created using the CLICK algorithm (Expander). Expression patterns for all clusters were standardized to mean zero and standard deviation one. Error bars correspond to one standard deviation. (PDF 360 kb)
Hagen, Martijn Van, Piebes, Diewertje, Leeuw, Wim De, Vuist, Ilona, Roon-Mom, Willeke Van, Moerland, Perry, Pernette Verschure   +6 more
openaire   +1 more source

Huntington\u27s Disease--A Review [PDF]

, 2016
Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core   +1 more source

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis [PDF]

, 2013
Although mutations in the huntingtin gene (HTT) due to poly-Q expansion cause neuropathology in humans (Huntington's disease; HD), the normal function(s) of the gene and its protein (HTT) remain obscure.
Brown, Euan R., Idris, Mohammed M, Thorndyke, Michael C   +2 more
core   +1 more source