Results 51 to 60 of about 10,552,439 (323)

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source

MOESM2 of The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntingtonâ s disease brain

, 2019
Additional file 2 PCA Outlier ...
Agus, Filisia, Crespo, Diego, Myers, Richard, Labadorf, Adam   +3 more
openaire   +1 more source

Astrocyte molecular signatures in Huntington’s disease

Science Translational Medicine, 2019
Astrocyte gene expression is altered in mouse models of Huntington’s disease and in postmortem brain samples from patients with HD. A shared signature Huntington’s disease is a neurodegenerative disorder caused by a dominant mutation in the HTT gene ...
Blanca Díaz-Castro, Mohitkumar R. Gangwani, Xinzhu Yu, G. Coppola, B. Khakh   +4 more
semanticscholar   +1 more source

Additional file 3 of Common disease signatures from gene expression analysis in Huntingtonâ s disease human blood and brain

, 2016
Modules in blood significantly correlated with HD. This file contains the 8 modules that were identified in blood as being correlated to the HD phenotype. The file describes each module according to the most representative annotations per semantic category (biological processes, cellular component, molecular function, disease or syndrome). (DOC 16.5 kb)
Mina, Eleni, Roon-Mom, Willeke Van, Hettne, Kristina, Zwet, Erik Van, Goeman, Jelle, Neri, Christian, Hoen, Peter A.C., Mons, Barend, Roos, Marco   +8 more
openaire   +1 more source

Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1 [PDF]

, 2022
Huntington’s disease is caused by an expanded CAG tract in HTT. The length of the CAG tract accounts for over half the variance in age at onset of disease, and is influenced by other genetic factors, mostly implicating the DNA maintenance machinery.
McDade-Kumar, Mia, Williams, Nigel M., Long, Jeffrey, Rosser, Anne, Landwehrmeyer, G Bernhard, Ryten, Mina, MacDonald, Marcy E, Orth, Michael, MacDonald, Marcy E., Gusella, James, Gusella, James F, Paulsen, Jane S., Long, Jeffrey D, Lobanov, Sergey, Holmans, Peter, Massey, Thomas, Massey, Thomas H, Landwehrmeyer, G. Bernhard, PREDICT-HD Investigators of the Huntington Study Group, Rosser, Anne E., Long, Jeffrey D., Jones, Lesley, Lobanov, Sergey V, REGISTRY Investigators of the European Huntington’s disease netw, Gusella, James F., Massey, Thomas H., Landwehrmeyer, Bernhard, Lee, Jong-Min, McAllister, Branduff, Williams, Nigel M, Paulsen, Jane S, Lobanov, Sergey V., Paulsen, Jane, Williams, Nigel, Rosser, Anne E, MacDonald, Marcy   +35 more
core   +1 more source

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington’s Disease

Frontiers in Neurology, 2017
The selection of an appropriate segmentation tool is a challenge facing any researcher aiming to measure gray matter (GM) volume. Many tools have been compared, yet there is currently no method that can be recommended above all others; in particular ...
Eileanoir B. Johnson, Sarah Gregory, Hans J. Johnson, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Raymund A. Roos, Geraint Rees, Sarah J. Tabrizi, Rachael I. Scahill   +9 more
doaj   +1 more source

Additional file 1 of Common disease signatures from gene expression analysis in Huntingtonâ s disease human blood and brain

, 2016
Significantly correlated modules in brain. This file contains the modules from each brain region (caudate, BA4, BA9 and cerebellum) that were associated with the disease phenotype. The numbers (P v a l u e) indicate the correlation of each module with the disease phenotype. Green: negative correlation, red: positive correlation.
Mina, Eleni, Roon-Mom, Willeke Van, Hettne, Kristina, Zwet, Erik Van, Goeman, Jelle, Neri, Christian, Hoen, Peter A.C., Mons, Barend, Roos, Marco   +8 more
openaire   +1 more source

Additional file 1 of Identify Huntingtonâ s disease associated genes based on restricted Boltzmann machine with RNA-seq data

, 2017
Supplementary Material. The detail derivation process for solving the gradients of RBMs learning is given in the Supplementary Material. (PDF 321 kb)
Jiang, Xue, Zhang, Han, Duan, Feng, Quan, Xiongwen   +3 more
openaire   +1 more source

DNA Mismatch Repair and its Role in Huntington’s Disease

Journal of Huntington's Disease, 2021
DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage.
R. Iyer, A. Pluciennik
semanticscholar   +1 more source

Meaningful and measurable health domains in Huntington’s Disease: large-scale validation of the Huntington’s Disease health-related quality of life questionnaire across severity stages [PDF]

, 2019
Background: although health-related quality of life is key for patients with long-term neurodegenerative conditions, measuring this is less straightforward and complex in Huntington’s disease (HD).Objectives: to refine and validate a fully patient ...
Burgunder, Jean-Marc, Tennant, Alan, European Huntington’s Disease Network, Ho, Aileen K., Landwehrmeyer, G. Bernhard, Horton, Mike C., Kipps, Chris   +6 more
core   +1 more source