Results 71 to 80 of about 10,466,444 (219)

Huntington's disease is a multi-system disorder. [PDF]

, 2015
Huntingtons disease (HD) is one of the most common non-curable rare diseases and is characterized by choreic movements, psychiatric symptoms, and slowly progressive dementia.
Mielcarek, M
core   +1 more source

Visual control improves the accuracy of hand positioning in Huntington’s disease

Aktualności Neurologiczne, 2017
Background: The study aimed at demonstrating dependence of visual feedback during hand and finger positioning task performance among Huntington’s disease patients in comparison to patients with Parkinson’s disease and cervical dystonia.
Emilia J. Sitek, Witold Sołtan, Agnieszka Konkel, Dariusz Wieczorek, Michał Schinwelski, Piotr Robowski, Jarosław Sławek   +6 more
doaj   +1 more source

Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series

Brain Sciences, 2020
Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington’s disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric symptoms, often ...
Jannis Achenbach, Charlotte Thiels, Thomas Lücke, Carsten Saft   +3 more
doaj   +1 more source

Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes [PDF]

, 2018
Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety
Campbell, Warren A., Chaibva, Maxmore, Frey, Shelli L., Gao, Xiang, Jain, Pranav, Legleiter, Justin   +5 more
core   +4 more sources

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

Lancet Neurology, 2017
Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We investigated whether neurofilament light protein NfL (also known as NF-L) in blood is a potential ...
L. Byrne, F. B. Rodrigues, K. Blennow, A. Durr, B. Leavitt, R. Roos, R. Scahill, S. Tabrizi, H. Zetterberg, D. Langbehn, E. Wild   +10 more
semanticscholar   +1 more source

The breaking point where repeat expansion triggers neuronal collapse in Huntington’s disease

Cell Genomics
Somatic CAG expansion drives neuronal loss in Huntington’s disease (HD), but how expansion results in pathogenesis has remained unclear. Handsaker et al.1 use single-cell RNA and repeat length sequencing to reveal a phased model of expansion and toxicity,
Michael D. Flower, Sarah J. Tabrizi
doaj   +1 more source

Juvenile Huntington’s disease

Анналы клинической и экспериментальной неврологии, 2017
Juvenile Huntingtons disease (JHD) manifests in 1st2nddecades of life and accounts for 29% of all cases ofHuntingtons disease; its pathogenic mechanisms are related togenetic anticipation and imprinting.
G. E. Rudenskaya, D. A. Savvin, V. P. Fedotov, S. A. Kurbatov, A. V. Polyakov, N. M. Galeeva   +5 more
doaj   +1 more source

Postoperative hematoma in cervical spondylosis patient complicated with Huntington’s disease: Case report and literature review

SAGE Open Medical Case Reports, 2023
Hematoma is a life-threatening complication of anterior surgery in cervical spondylosis patients. Herein, we report a cervical spondylosis patient complicated with Huntington’s disease, who developed unexpected neck hematoma after anterior cervical ...
Zifan Zhang, Chen Xu, Guoqing Wen, Minjie Dong, Xiaolong Shen, Baofeng Gong, Baifeng Sun, Min Qi, Ye Tian, Yang Liu, Wen Yuan   +10 more
doaj   +1 more source

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin [PDF]

, 2009
Background: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage
Brundin, Patrick, Khoshnan, Ali, Ko, Jan, Patterson, Paul H., Tescu, Simona   +4 more
core   +3 more sources

International Guidelines for the Treatment of Huntington's Disease

Frontiers in Neurology, 2019
The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice for treatment of Huntington's disease (HD). The objectives of such guidelines are to
A. Bachoud-Lévi, J. Ferreira, R. Massart, K. Youssov, A. Rosser, M. Busse, D. Craufurd, R. Reilmann, G. De Michele, D. Rae, F. Squitieri, K. Seppi, Charles Perrine, C. Scherer-Gagou, O. Audrey, C. Verny, J. Burgunder   +16 more
semanticscholar   +1 more source