Results 71 to 80 of about 4,904,701 (256)

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK

Royal Society Open Science
We develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost.
Andrew Pollard, Danica Greetham, James Myatt, Hugh Rickards, Cath Stanley, Dave Dungate   +5 more
doaj   +1 more source

Raman spectroscopy of fibroblast cells from a Huntington’s disease patient

, 2015
Raw dataset for Downes (2015) "Raman spectroscopy of fibroblast cells from a Huntington’s disease patient" In Submission. Set of Raman spectra from 20 individual cells from a patient with Huntington's disease (GM04281, Coriell Cell repository) and from ...
Downes, Andy
core   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2006
In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz, Ian Q. Whishaw, Afra Foroud, Nafisa M. Jadavji   +3 more
doaj  

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on ...
Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione   +6 more
wiley   +1 more source

Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting. [PDF]

PLoS ONE, 2015
There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Fetal ...
Laurent Cleret de Langavant, Sophie Sudraud, Christophe Verny, Pierre Krystkowiak, Clémence Simonin, Philippe Damier, Jean-François Demonet, Frédéric Supiot, Amandine Rialland, David Schmitz, Patrick Maison, Katia Youssov, Anne-Catherine Bachoud-Lévi   +12 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse

, 2006
Neural stem and progenitor cells are located in the subependyma of the adult forebrain. An increase in adult subependymal cell proliferation is reported after various kinds of brain injury.
Batista, C.M.C., Akamatsu, W., Shimabukuro, M.K., Kippin, T.E., Willaime-Morawek, S., van der Kooy, D.   +5 more
core   +1 more source

Predicting clinical scores in Huntington’s disease: a lightweight speech test

, 2022
OBJECTIVES: Using brief samples of speech recordings, we aimed at predicting, through machine learning, the clinical performance in Huntington’s Disease (HD), an inherited Neurodegenerative disease (NDD). METHODS: We collected and analyzed 126 samples of
Montillot, Justine, Cleret de Langavant, Laurent, Cao, Xuan-Nga, Dupoux, Emmanuel, Youssov, Katia, Lunven, Marine, Hamet Bagnou, Jennifer, Bachoud-Lévi, Anne-Catherine, Titeux, Hadrien, Riad, Rachid, Lemoine, Laurie, Sliwinski, Agnes   +11 more
core   +1 more source