Results 81 to 90 of about 10,466,444 (219)

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

PLoS ONE, 2015
Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis.
James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi   +3 more
doaj   +1 more source

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

Nature Neuroscience, 2018
In Huntington’s disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs).
Matheus B. Victor, M. Richner, Hannah E. Olsen, S. Lee, A. M. Monteys, Chunyu Ma, Christine J. Huh, Bo Zhang, Beverly L. Davidson, Beverly L. Davidson, X. W. Yang, Andrew S. Yoo   +11 more
semanticscholar   +1 more source

Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK

Royal Society Open Science
We develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost.
Andrew Pollard, Danica Greetham, James Myatt, Hugh Rickards, Cath Stanley, Dave Dungate   +5 more
doaj   +1 more source

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Biological and clinical manifestations of Huntington’s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

Lancet Neurology, 2009
Summary Background Huntington’s disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in mid-life.
S. Tabrizi, D. Langbehn, B. Leavitt, R. Roos, A. Durr, D. Craufurd, C. Kennard, S. Hicks, Nick C Fox, R. Scahill, B. Borowsky, A. Tobin, H. Rosas, H. Johnson, R. Reilmann, B. Landwehrmeyer, J. Stout   +16 more
semanticscholar   +1 more source

Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2006
In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz, Ian Q. Whishaw, Afra Foroud, Nafisa M. Jadavji   +3 more
doaj  

Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting. [PDF]

PLoS ONE, 2015
There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Fetal ...
Laurent Cleret de Langavant, Sophie Sudraud, Christophe Verny, Pierre Krystkowiak, Clémence Simonin, Philippe Damier, Jean-François Demonet, Frédéric Supiot, Amandine Rialland, David Schmitz, Patrick Maison, Katia Youssov, Anne-Catherine Bachoud-Lévi   +12 more
doaj   +1 more source

The Coherence of Evolutionary Theory with Its Neighboring Theories [PDF]

, 2019
Evolutionary theory coheres with its neighboring theories, such as the theory of plate tectonics, molecular biology, electromagnetic theory, and the germ theory of disease.
Park, Seungbae
core   +3 more sources

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Nature Communications, 2019
Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain cells.
Jian-Jing Siew, Hui-Mei Chen, Huan-Yuan Chen, Hung-Lin Chen, C. Chen, B. Soong, Yih-Ru Wu, Ching-Pang Chang, Yi-Chen Chan, Chun-Hung Lin, Fu-Tong Liu, Y. Chern   +11 more
semanticscholar   +1 more source

Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study

Revista Finlay, 2023
Foundation: biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker.
Marisol Peña Sánchez, Gabriel Andrés Peña de los Santos, Gretel Riverón Forment, Gloria Lara Fernández, Tatiana Acosta Sánchez, Alina González-Quevedo Monteagudo   +5 more
doaj