Results 81 to 90 of about 10,552,439 (323)

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Neuron, 2019
Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein.
S. Tabrizi, R. Ghosh, B. Leavitt
semanticscholar   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Huntington's Disease

Pediatric Neurology Briefs, 1989
The positron-emission tomography (PET) findings in a seven year old girl with the juvenile form of Huntington's disease are described from the Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, Canada.
J Gordon Millichap
doaj   +1 more source

Therapies targeting DNA and RNA in Huntington's disease

Lancet Neurology, 2017
Summary No disease-slowing treatments exist for Huntington’s disease (HD), but its monogenic inheritance makes it an appealing candidate for the development of therapeutics targeting pathogenic processes close to its root genetic cause.
E. Wild, S. Tabrizi
semanticscholar   +1 more source

Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats [PDF]

Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner.
Krygier, Magdalena, Zielonka, Daniel, Romano, Silvia, Limon, Janusz, Stanisławska-Sachadyn, Anna, Ziętkiewicz, Ewa, Sławek, Jarosław, REGISTRY investigators of the European Huntington’s Disease Network (EHDN), Krzemiński, Michał   +8 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series

Brain Sciences, 2020
Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington’s disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric symptoms, often ...
Jannis Achenbach, Charlotte Thiels, Thomas Lücke, Carsten Saft   +3 more
doaj   +1 more source

Postoperative hematoma in cervical spondylosis patient complicated with Huntington’s disease: Case report and literature review

SAGE Open Medical Case Reports, 2023
Hematoma is a life-threatening complication of anterior surgery in cervical spondylosis patients. Herein, we report a cervical spondylosis patient complicated with Huntington’s disease, who developed unexpected neck hematoma after anterior cervical ...
Zifan Zhang, Chen Xu, Guoqing Wen, Minjie Dong, Xiaolong Shen, Baofeng Gong, Baifeng Sun, Min Qi, Ye Tian, Yang Liu, Wen Yuan   +10 more
doaj   +1 more source

β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease [PDF]

, 2013
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a CAG triplet repeat tract in the huntingtin gene. While the length of this CAG expansion is the major determinant of the age of onset (AO),
ROMANO, SILVIA, Giorgini, Flaviano, Orth, Michael, Outeiro, Tiago F, Vittori, Angelica, Registry, investigators of the European Huntington’s Disease Network, Roos, Raymund A. C, Hollox, Edward J   +7 more
core   +3 more sources