The Role of Microglia and Astrocytes in Huntington’s Disease
Frontiers in Molecular Neuroscience, 2019 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms and cognitive decline.
T. Palpagama +3 more
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Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
Molecular MedicineBackground The disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin (HTT) gene. The mutated CAG tract results in the production of a small RNA, HTT1a, coding for only exon 1 of HTT.
Franziska Hoschek +8 more
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Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology
Journal of Neuroscience, 1999 The data we report in this study concern the types, location, numbers, forms, and composition of microscopic huntingtin aggregates in brain tissues from humans with different grades of Huntington’s disease (HD).
C. Gutekunst +9 more
semanticscholar +1 more source
Two-photon imaging of cell-specific fluorophores in transgenic mice – an exploratory tool to study mechanisms of white matter injury [PDF]
, 2006 Relatively little is known about specific pathways leading to structural and functional disruption of axons and glial cells in white matter. Because focal cerebral ischemia in humans damages both gray and white matter, an understanding of white matter ...
6th Maltese Medical School Conference +2 more
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Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, N +5 more
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Neuroimaging in Huntington’s disease [PDF]
Анналы клинической и экспериментальной неврологииHuntington’s disease (HD) is an autosomal dominant progressive neurodegenerative disorder for which effective disease-modifying treatments have not yet been developed. Current diagnosis of HD relies on clinical criteria and genetic testing.
George A. Anikin +4 more
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Detection of Huntington’s disease decades before diagnosis: the Predict-HD study
Journal of Neurology Neurosurgery & Psychiatry, 2007 Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical markers to understand the early progression of Huntington’s disease (HD), prior to the point of traditional diagnosis, in persons with a known gene ...
Jane S. Paulsen +15 more
semanticscholar +1 more source
Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]
, 2019 Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis +13 more
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The human olfactory bulb in Huntington's disease: sex-specific differences in volume and gliosis
Neurobiology of DiseaseHuntington's disease is a multisystemic neurodegenerative disorder for which increasing evidence suggests early involvement of brain regions beyond the primarily affected motor areas of the brain, such as the olfactory bulb, which is affected by multiple
Ana Paula Flores-Thomas +8 more
doaj +1 more source
A Case Report: Psychotic Disorder Related to Huntington‘s Disease [PDF]
Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2004 Basal ganglia disorders are characterised by the presence of abnormal movements, psychiatric signs and symptoms, and varying degrees of cognitive impairment. Huntington's disease (HD), one of basal ganglia disorders is is an autosomal, dominant disorder.
Çağatay Karşıdağ +5 more
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