Results 101 to 110 of about 10,552,439 (323)

International Guidelines for the Treatment of Huntington's Disease

Frontiers in Neurology, 2019
The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice for treatment of Huntington's disease (HD). The objectives of such guidelines are to
A. Bachoud-Lévi, J. Ferreira, R. Massart, K. Youssov, A. Rosser, M. Busse, D. Craufurd, R. Reilmann, G. De Michele, D. Rae, F. Squitieri, K. Seppi, Charles Perrine, C. Scherer-Gagou, O. Audrey, C. Verny, J. Burgunder   +16 more
semanticscholar   +1 more source

Huntington’s disease: a perplexing neurological disease [PDF]

, 2015
Huntington’s disease is an inherited intricate brain illness. It is a neurodegenerative, insidious disorder; the onset of the disease is very late to diagnose.
Gundamaraju, R, Vemuri, R
core   +2 more sources

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK

Royal Society Open Science
We develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost.
Andrew Pollard, Danica Greetham, James Myatt, Hugh Rickards, Cath Stanley, Dave Dungate   +5 more
doaj   +1 more source

APY766120_Appendix – Supplemental material for Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease [PDF]

, 2018
Supplemental material, APY766120_Appendix for Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease by Samantha M Loi, Mark Walterfang, Dennis Velakoulis and Jeffrey CL Looi in Australasian ...
Jeffrey CL Looi (5196482), Mark Walterfang (296530), Dennis Velakoulis (296515), Samantha M Loi (5196479)   +3 more
core   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2006
In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz, Ian Q. Whishaw, Afra Foroud, Nafisa M. Jadavji   +3 more
doaj  

Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting. [PDF]

PLoS ONE, 2015
There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Fetal ...
Laurent Cleret de Langavant, Sophie Sudraud, Christophe Verny, Pierre Krystkowiak, Clémence Simonin, Philippe Damier, Jean-François Demonet, Frédéric Supiot, Amandine Rialland, David Schmitz, Patrick Maison, Katia Youssov, Anne-Catherine Bachoud-Lévi   +12 more
doaj   +1 more source

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

Nature Neuroscience, 2018
In Huntington’s disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs).
Matheus B. Victor, M. Richner, Hannah E. Olsen, S. Lee, A. M. Monteys, Chunyu Ma, Christine J. Huh, Bo Zhang, Beverly L. Davidson, Beverly L. Davidson, X. W. Yang, Andrew S. Yoo   +11 more
semanticscholar   +1 more source

Huntington’s Disease Clinical Trials Corner: February 2018 [PDF]

, 2018
In the second edition of the Huntington’s Disease Clinical Trials Corner we list all currently registered and ongoing clinical trials, summarise the top-line results of the recently-announced IONIS-HTTRX trial (NCT02519036), expand on Wave Life Sciences’
Wild, Edward J., Brogueira Rodrigues, FA, Wild, EJ, Rodrigues, Filipe Brogueira, Filipe B. Rodrigues, Edward J. Wild   +5 more
core   +1 more source