Results 121 to 130 of about 10,466,444 (219)

Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease

Nature Communications
Hyperconnectivity in functional brain networks occurs decades before disease onset in Huntington’s disease. However, the biological mechanisms remain unknown. We investigate connectivity in Huntington’s disease using Morphometric INverse Divergence (MIND)
Carlos Estevez-Fraga, Isaac Sebenius, Justine Y. Hansen, Benjamin Hänisch, Paul Zeun, Rachael I. Scahill, Sarah Gregory, Eilanoir B. Johnson, Edward J. Wild, Lauren M. Byrne, Alexandra Durr, Bernhard Landwehrmeyer, Blair R. Leavitt, Bratislav Misic, Sofie Louise Valk, Geraint Rees, Sarah J. Tabrizi, Peter McColgan   +17 more
doaj   +1 more source

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice

Translational Neurodegeneration
Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials.
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden   +13 more
doaj   +1 more source

Physiotherapy in Huntington’s disease

Fysioterapeuten, 2013
Introduction:Huntington’s disease is hereditary and causes motor, cognitive and behavioural symptoms that progress over time. The aim of this article is to describe the disease and to highlight why physiotherapy is important and to point out potential ...
Hanne Ludt Fossmo, Anu Piira, Jeanette Ullmann Miller, Jan C. Frich   +3 more
doaj  

Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease.

Journal of applied physiology, 1997
Jeffrey M. Hausdorff, S. Mitchell, R. Firtion, Chung-Kang Peng, M. Cudkowicz, J. Wei, A. Goldberger   +6 more
semanticscholar   +1 more source

Pain processing and pain assessment in Huntington's disease: Study protocol of the Huntington's disease - PAIN study. [PDF]

PLoS One
Sprenger GP, van Velzen M, Achterberg WP, Roos RAC, de Bot ST.   +4 more
europepmc   +1 more source

Novel Compounds for Treating Huntington's Disease. [PDF]

ACS Med Chem Lett
Sabnis RW, Sabnis AR.
europepmc   +1 more source

Life Without Hope? Huntington\u27s Disease and Genetic Futurity [PDF]

, 2013
Canavan, Gerry
core   +1 more source

Effect of tetrabenazine on Stroop interference in Huntington's disease: Protocol. [PDF]

MethodsX
Fekete R.
europepmc   +1 more source

Bridging the gap: sex-specific differences in Huntington's disease. [PDF]

Orphanet J Rare Dis
Hemicker G, Schwarzová K, Labrecque S, Cerejo C, Carbone F, Peball M, Wimmer B, Mahlknecht P, Krismer F, Djamshidian A, Seppi K, Heim B.   +11 more
europepmc   +1 more source

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Proceedings of the National Academy of Sciences of the United States of America, 2000
J. Steffan, A. Kazantsev, O. Spasic-Boskovic, Marilee Greenwald, Ya-zhen Zhu, H. Göhler, E. Wanker, G. Bates, D. Housman, L. Thompson   +9 more
semanticscholar   +1 more source