Results 121 to 130 of about 4,904,701 (256)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Deconstructing Ataxia with Oculomotor Apraxia: Toward a Gene‐Based Classification and a Reappraisal of the Oculomotor Phenotype

Movement Disorders Clinical Practice, EarlyView.
Luiz Eduardo Novis, Flávio Moura Rezende Filho, Anna Maria Gomes, Victor Rebelo Procaci, Orlando Graziani Povoas Barsottini, José Luiz Pedroso   +5 more
wiley   +1 more source

Enhance food plant diversity conservation and use through greater coordination between genebanks and botanic gardens

PLANTS, PEOPLE, PLANET, EarlyView.
Food plants are vital to human and planetary health, but their diversity is threatened, making food security, nutrition, and environmental goals more difficult to achieve. Food plant diversity conservation, research, and education can be enhanced through collaboration between sectors, including genebanks and botanic gardens, which possess complementary
Colin K. Khoury, Sarah Gora, Hannes Dempewolf, Mauricio Diazgranados, Alex C. McAlvay, Vania Azevedo, Sam Brockington, Ángela Cano, Daniel Carver, Carly Cowell, Peter Crane, Cary Fowler, Peter Giovannini, Luigi Guarino, Robbie Hart, Geoff Hawtin, Sarada Krishnan, Charlotte Lusty, Patricia Malcolm, Nan McCarry, Abby Meyer, Allison Miller, Ray Mims, Tara Moreau, Arshiya Noorani, Susan K. Pell, Juan Lucas Restrepo, Erin C. Riordan, Stefan Schmitz, Paul Smith, Charles Spillane, Alvaro Toledo, Raakel Toppila, Maarten van Zonneveld, Emily Warschefsky, Peter Wenzl   +35 more
wiley   +1 more source

Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease

Nature Communications
Hyperconnectivity in functional brain networks occurs decades before disease onset in Huntington’s disease. However, the biological mechanisms remain unknown. We investigate connectivity in Huntington’s disease using Morphometric INverse Divergence (MIND)
Carlos Estevez-Fraga, Isaac Sebenius, Justine Y. Hansen, Benjamin Hänisch, Paul Zeun, Rachael I. Scahill, Sarah Gregory, Eilanoir B. Johnson, Edward J. Wild, Lauren M. Byrne, Alexandra Durr, Bernhard Landwehrmeyer, Blair R. Leavitt, Bratislav Misic, Sofie Louise Valk, Geraint Rees, Sarah J. Tabrizi, Peter McColgan   +17 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

ALTERED EXPRESSION AND FUNCTIONALITY OF A2A ADENOSINE RECEPTORS IN HUNTINGTON’S DISEASE AND OTHER POLYGLUTAMINE DISORDERS [PDF]

, 2009
Several studies have suggested the possible involvement of A2A adenosine receptors in the pathogenesis of neuronal disorders, including Huntington’s disease.
Vincenzi, Fabrizio
core  

Using Harvest Data to Assess Factors Influencing Regional Population Declines of Muskrats (Ondatra zibethicus) 利用捕获数据评估影响麝鼠 (Ondatra zibethicus) 区域种群数量下降的相关因素

Wildlife Letters, EarlyView.
Reported annual per‐capita harvest of muskrats (PCHM) decreased as wetland complexity (total number of wetland patches) decreased in 13 state and federal wetland areas in the Midwest, USA. Our results support the hypothesis that regional‐scale declines in the abundance of muskrats are likely associated with the losses to wetland habitats throughout the
Tim L. Hiller, Andrea Sylvia, Jesse T. Boulerice, Adam A. Ahlers, Dwayne R. Etter, Eric M. Dunton   +5 more
wiley   +1 more source

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

The Timely Rise of a Teenage Reformer: Youth Revolt, Feminism and the Struggle for a ‘New Sexual Morality’ at the Dawn of the Spanish Second Republic

Gender &History, EarlyView.
ABSTRACT The contributions of propagandist and writer Hildegart (1914–1933) to Spanish cultural life are overshadowed by accounts of her unusual upbringing and violent death. This article examines the conditions that enabled the teenager to become a prominent voice for feminism and sexual reform on the eve of Spain's Second Republic (1931–1939).
Micaela Pattison
wiley   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source