Results 131 to 140 of about 4,904,701 (256)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

The ‘hidden no more’ mass lobby June 2010 - using oral histories and cultural representations to explore the concealment of Huntington’s disease [PDF]

Harrison, Jacqueline Sophie
core   +3 more sources

Automatic selection model to identify neurodegenerative diseases

Digital Health
Objective This study evaluates machine learning algorithms’ effectiveness in classifying Parkinson’s disease and Huntington’s disease based on biomarker data obtained non-invasively from patients and healthy controls.
Eddy Sánchez-DelaCruz, Cecilia-Irene Loeza-Mejía, César Primero-Huerta, Mirta Fuentes-Ramos   +3 more
doaj   +1 more source

Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao, Pijun Cheng, Fusong Jiang, Wenmin Li, Yingying Shi, Wenjun Wang, Liang Wang, Tao Lei, Yunxiang Zang, Jun Lu   +9 more
wiley   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Physiotherapy in Huntington’s disease

Fysioterapeuten, 2013
Introduction:Huntington’s disease is hereditary and causes motor, cognitive and behavioural symptoms that progress over time. The aim of this article is to describe the disease and to highlight why physiotherapy is important and to point out potential ...
Hanne Ludt Fossmo, Anu Piira, Jeanette Ullmann Miller, Jan C. Frich   +3 more
doaj  

Episodic memory rehabilitation for HIV‐associated neurocognitive disorders: A scoping review

Journal of Neuropsychology, EarlyView.
Abstract Despite extensive research on HIV‐associated neurocognitive disorders (HAND), interest in cognitive rehabilitation has emerged only within the past 15 years. HAND are characterised by mild‐to‐moderate impairments in multiple cognitive domains: attention, episodic memory and executive functions.
Signe Andersen, Sylvane Faure
wiley   +1 more source

Developing a neuropsychiatry curriculum for clinical psychologists and neuropsychologists: An e‐Delphi study

Journal of Neuropsychology, EarlyView.
Abstract Neuropsychiatric presentations are common across neurological and mental health services but they are often inadequately covered by core clinical psychology and clinical neuropsychology training. Consequently, we aimed to identify components for a neuropsychiatry curriculum for clinical psychologists using a Delphi process.
Keishema Kerr, Tamara Anderson, Graham Blackman, Amy Copping, Niels Detert, Alexandra Garfield, Peter Gilli, Laura H. Goldstein, Huw Green, Simon Harrison, Leigh Leppard, Norman Poole, Torie Robinson, Alexandra Rose, Biba Stanton, Mary Summers, Victoria Teggart, Mike Wang, Vaughan Bell   +18 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source