Results 131 to 140 of about 10,552,439 (323)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

The Role of Microglia and Astrocytes in Huntington’s Disease

Frontiers in Molecular Neuroscience, 2019
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms and cognitive decline.
T. Palpagama, H. Waldvogel, R. Faull, A. Kwakowsky   +3 more
semanticscholar   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Neuroimaging in Huntington’s disease [PDF]

Анналы клинической и экспериментальной неврологии
Huntington’s disease (HD) is an autosomal dominant progressive neurodegenerative disorder for which effective disease-modifying treatments have not yet been developed. Current diagnosis of HD relies on clinical criteria and genetic testing.
George A. Anikin, Sergey A. Klyushnikov, Alexey S. Filatov, Alina A. Liaskovik, Sergey N. Illarioshkin   +4 more
doaj   +1 more source

Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology

Journal of Neuroscience, 1999
The data we report in this study concern the types, location, numbers, forms, and composition of microscopic huntingtin aggregates in brain tissues from humans with different grades of Huntington’s disease (HD).
C. Gutekunst, Shihua Li, Hong Yi, James S. Mulroy, S. Kuemmerle, Randi Jones, David Rye, R. Ferrante, S. Hersch, Xiao-Jiang Li   +9 more
semanticscholar   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Functional connectivity of the prefrontal cortex in Huntington’s disease [PDF]

, 2007
Background: Huntington’s disease is a progressive neurodegenerative disorder that results in deterioration and atrophy of various brain regions. Aim: To assess the functional connectivity between prefrontal brain regions in patients with Huntington’s ...
Farrow, M., Georgiou-Karistianis, N., Sritharan, A., Cunnington, R., Egan, G. F., Brawn, T-L., Churchyard, A., Chua, P., Ray, S., Bradshaw, J. L., Thiruvady, D. R.   +10 more
core   +1 more source

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source

Longitudinal assessment of chorea in Huntington’s disease using digital passive monitoring

npj Digital Medicine
Chorea is a hallmark of Huntington’s disease (HD), yet its clinical assessment is of limited reliability, impairing our ability to sensitively evaluate its progression.
Claire Lugrin, Lidia Alecci, Cedric Simillion, Ekaterina Volkova-Volkmar, Louis-Solal Giboin, Fiona C. Kinsella, Peter McColgan, Edward J. Wild, Jonas Dorn   +8 more
doaj   +1 more source

A Case Report: Psychotic Disorder Related to Huntington‘s Disease [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2004
Basal ganglia disorders are characterised by the presence of abnormal movements, psychiatric signs and symptoms, and varying degrees of cognitive impairment. Huntington's disease (HD), one of basal ganglia disorders is is an autosomal, dominant disorder.
Çağatay Karşıdağ, Rıdvan Üney, Ahmet Kocabıyık, Reşit Kükürt, Nihat Alpay, Cengiz Dayan   +5 more
doaj