Results 111 to 120 of about 10,552,439 (323)
Lancet Neurology, 2009 Summary Background Huntington’s disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in mid-life.
S. Tabrizi +16 more
semanticscholar +1 more source
Animal Research and One Health, EarlyView.This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou +4 more
wiley +1 more source
Experimental and Molecular Medicine, 2019 Huntington’s disease: Diabetes drug limits disease-related degeneration in mice Metformin, an existing drug for diabetes, shows promise in alleviating symptoms of early Huntington’s disease in mouse models. Huntington’s disease is a genetic disorder that
Ana Sanchis +6 more
doaj +1 more source
Nature Communications, 2019 Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain cells.
Jian-Jing Siew +11 more
semanticscholar +1 more source
Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles
BMEMat, EarlyView.Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu +9 more
wiley +1 more source
Disease stage, but not sex, predicts depression and psychological distress in Huntington’s disease : A European population study [PDF]
, 2015 Objective Depression and anxiety significantly affect morbidity in Huntington’s disease. Mice models of Huntington’s disease have identified sex differences in mood-like behaviours that vary across disease lifespan, but this interaction has not ...
Maria Dale (7634207) +5 more
core
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Factor Analysis of the Hospital Anxiety and Depression Scale among a Huntington’s Disease Population [PDF]
, 2015 Background Depression and anxiety are common in Huntington’s Disease, a genetic neurodegenerative disorder. Objectives There is a need for measurement tools of mood to be validated within a Huntington’s disease population.
Maria Dale (7634207) +4 more
core
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, EarlyView.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
core +2 more sources