Results 151 to 160 of about 4,904,701 (256)

Irritability in the Mix: An Exploratory Study of the Role of Irritability in Characterising Mood Disorders

Bipolar Disorders, Volume 28, Issue 7, November 2026.
ABSTRACT Objectives To examine the relationship between irritability and mixed states in bipolar disorder to determine how subjective irritability and mixed symptoms of mania and depression manifest in patients with bipolar disorder over a period of 18 months.
Erica Bell, Maree Inder, Gin S. Malhi, Richard Bryant, Philip Boyce, Richard J. Porter   +5 more
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Functional Heterogeneity of the Autism Spectrum Disorder‐Associated Gut Microbial Ecosystem Revealed by Fecal Lipopolysaccharides and Bacterial Proteomic Profiling

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
Gut microbiota associated with pediatric autism spectrum disorder exhibit functional heterogeneity characterized by altered fecal lipopolysaccharide landscapes, metabolic remodeling, and enhanced microglial inflammatory responses despite largely preserved microbial composition.
Stefania De Chiara, Angela Di Somma, Valentina Mazziotti, Serena Coppola, Franca Oglio, Lidia Tammaro, Maria Pia Riccio, Carmela Bravaccio, Antonio Molinaro, Roberto Berni Canani, Flaviana Di Lorenzo   +10 more
wiley   +1 more source

Pain processing and pain assessment in Huntington's disease: Study protocol of the Huntington's disease - PAIN study. [PDF]

PLoS One
Sprenger GP, van Velzen M, Achterberg WP, Roos RAC, de Bot ST.   +4 more
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Exploring the association between antidepressants, progression and mortality in Huntington's disease. [PDF]

Brain
McLauchlan D, Drew C, Holmans P, Rosser A.   +3 more
europepmc   +1 more source

GLP‐1R agonist semaglutide protects human forebrain organoids from cholesterol‐induced neurotoxicity

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Dysregulated cholesterol metabolism represents a critical metabolic stressor in the central nervous system, contributing to neuronal injury across multiple neurological conditions, including Alzheimer's disease (AD). While glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show neuroprotective potential, their capacity to directly
Feifei Yu, Jiani Xu, Yibo Hou, Honghui Zheng, Lingyi Guo, Davit Khutsishvili, Cheng Hai, Wenxin Xu, Bailing Chen, Zitian Wang, Shaohua Ma   +10 more
wiley   +1 more source

Novel Compounds for Treating Huntington's Disease. [PDF]

ACS Med Chem Lett
Sabnis RW, Sabnis AR.
europepmc   +1 more source

Regional and Compartmental Changes Drive Progressive Patterns of Striatal Degeneration in X‐Linked Dystonia Parkinsonism

Annals of Neurology, Volume 100, Issue 4, Page 751-767, October 2026.
Objective Initially described in 1976, X‐linked dystonia parkinsonism (XDP) is a neurodegenerative disease that can be characterized by the presentation of dystonia and parkinsonism symptoms. Although this disease bears some resemblance to other neurodegenerative diseases in terms of symptomatology, the pathological signature of XDP is still unclear ...
Adelie Y.S. Tan, Nakhon. S.S.S. Thai, Christine J. Arasaratnam, Seung A. Han, Ellen B. Penney, Geraldine Acuña‐Sunshine, Cid Czarina E. Diesta, Mark C. Ang, Edwin Muñoz, Cara Fernandez‐Cerado, Victor Cleofas, G. Paul Legarda, Salvie Velasco, Michelle A. Sy, Clinton P. Turner, Mike Dragunow, Maurice A. Curtis, Ann. M. Graybiel, Richard L.M. Faull, Malvindar K. Singh‐Bains   +19 more
wiley   +1 more source

Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates. [PDF]

J Neurol Neurosurg Psychiatry
Lunven M, Van Den Enden P, Gil Salcedo A, Pertzov Y, Bapst B, Youssov K, Morgado G, Busse M, Massart R, Rosser A, Bachoud-Lévi AC.   +10 more
europepmc   +1 more source