Results 161 to 170 of about 4,904,701 (256)

Synergistic Cytotoxicity of Cafestol and Kahweol With Doxorubicin in Breast Cancer Cells Involves TNF‑α Targeting and NF‑κB Downregulation

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
Cafestol and kahweol (C&K) are cytotoxic to breast cancer cells and have a synergistic effect with doxorubicin. C&K interact with TNF‐α and downregulate the TNF‐α/NF‐κB pathway, underscoring their therapeutic potential for breast cancer. NIAID Visual & Medical Arts. Generic Cells. NIAID NIH BIOART Source. bioart.niaid.nih.gov/bioart/171. NIAID Visual &
Layane D. Souza, Fábio Junior M. Novaes, Carlos Luan A. Passos, Ísis S. S. de Amorim, Pedro Nicolau‐Neto, Juliana A. Rodrigues, Adilson F. Teixeira, Christian Ferreira, Nathalia Alexia N. dos Santos, Priscila G. Camargo, Marcelle L. F. Bispo, Camilo Henrique S. Lima, Bruno Ricardo B. Pires, Adenilson de Sousa da Fonseca, Claudia M. Rezende, Eliane Fialho, Andre Luiz Mencalha   +16 more
wiley   +1 more source

The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington's disease. [PDF]

Brain
Papadopoulou AS, Landles C, Smith EJ, Bondulich MK, Boeddrich A, Canibano-Pico M, Danby ECE, Hoschek F, Iqbal A, Jones ST, Neuendorf N, Nita IM, Osborne GF, Phillips J, Wagner M, Wanker EE, Greene JR, Neueder A, Bates GP.   +18 more
europepmc   +1 more source

Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI–ALPS Study

Brain and Behavior, Volume 16, Issue 10, October 2026.
Glymphatic function, assessed by DTI‐ALPS index, was impaired in neurological Wilson's disease compared with hepatic phenotype and controls. Age, AST, and UWDRS‐I score independently predicted dysfunction, linking neurodegeneration, liver injury, and altered glymphatic activity. ABSTRACT Background Wilson's disease (WD) is a genetic disorder of copper (
Ling Zhu, Tong Wu, Liang‐Jie Zhang, Qin‐yuan Liu, Liang‐liang Zhang, Bin Song, Yu‐long Zhu, Lei Hua, Long Zhang, Bo Li, Quan Sun, Ben‐chun Xue, Yin Xu, Yong‐zhu Han, Yong‐sheng Han   +14 more
wiley   +1 more source

Geometric properties of caudate and putamen mark the progression of Huntington's disease. [PDF]

Imaging Neurosci (Camb)
Pustina D, Bogale H, Das S, Avants B, Sathe S, Sampaio C, Wood A.   +6 more
europepmc   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro‐QoL Cognition Function Scale

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Primary brain tumor (PBT) patients commonly experience cognitive dysfunction. This study aims to describe the prevalence and factors associated with perceived cognitive function (PCF) in PBT patients enrolled in a natural history study (NCT02851706: Principal Investigator T. S. Armstrong).
Morgan Johnson, Kimberly Reinhart, Vivian A. Guedes, Michelle L. Wright, Elizabeth Vera, Alvina Acquaye‐Mallory, Hope Miller, Anna Choi, Tricia Kunst, Jennifer Reyes, Jing Wu, Marta Penas‐Prado, Byram Ozer, Eric Burton, Mark R. Gilbert, Terri S. Armstrong, Tito Mendoza   +16 more
wiley   +1 more source

Decreased cerebrospinal fluid TNFRSF8 (sCD30) confirmed as a biomarker of Huntington's disease progression. [PDF]

J Neurol
Grétarsdóttir HM, Cunningham JL, Rasmusson A, Burman J, Kultima K, Paucar M, Svenningsson P, Constantinescu R, Niemelä V.   +8 more
europepmc   +1 more source

Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
GC‐MS fingerprinting demonstrated that ethanolic leaf extract of Sanchezia nobilis (SNE) many phytochemicals out of which aniline and isoquinoline showed potential binding affinity to alpha1GABAA receptor responsible for anxiolytic effects. In vitro studies confirmed antioxidant effects of SNE.
Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar   +9 more
wiley   +1 more source

Assessing the prognostic value of early oculomotor abnormalities in Huntington's disease. [PDF]

Front Neurol
Kaddoura A, Dalbro SEJ, van Walsem MR, Pihlstrøm L.   +3 more
europepmc   +1 more source

Unmasking Huntington Disease: How a Neuropsychiatric Crisis Overcame Cultural Barriers to a Delayed Diagnosis

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Huntington disease is an autosomal dominant neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric dysfunction. We report the case of a 53‐year‐old man who presented after a suicide attempt involving pesticide ingestion, following years of worsening choreiform movements, reported cognitive decline, and severe
Charles Donkor‐Baah, George Harold Kitson‐Mills, Stephen Annan Arthur, Irene Acquah   +3 more
wiley   +1 more source