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Mitochondrion (Amsterdam. Print), 2023
Misfolded proteins in the central nervous system can induce oxidative damage, which can contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients face early mitochondrial dysfunction, impacting energy utilization. Amyloid-ß
T. Alqahtani +14 more
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Misfolded proteins in the central nervous system can induce oxidative damage, which can contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients face early mitochondrial dysfunction, impacting energy utilization. Amyloid-ß
T. Alqahtani +14 more
semanticscholar +1 more source
Study of the Huntingtonâs disease pathogenesis with primary dermal fibroblasts of patients
2023The given work is devoted Detection of the pathological phenotype of Huntingtons disease at the cellular level in the study of primary dermal fibroblasts of patients. The methods used in this work are cell culturing of primary human dermal fibroblasts, immunofluorescent staining, western blotting.
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Biological and clinical manifestations of juvenile Huntington's disease: a retrospective analysis.
Lancet Neurology, 2018BACKGROUND Huntington's disease is a rare, neurodegenerative disease caused by an expanded CAG repeat mutation in the huntingtin gene. Compared with adult-onset Huntington's disease, juvenile Huntington's disease (onset ≤20 years) is even rarer and has ...
C. Fusilli +18 more
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Huntington's disease: from molecular pathogenesis to clinical treatment
Lancet Neurology, 2011C. Ross, S. Tabrizi
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