Results 171 to 180 of about 4,904,701 (256)

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Molecular Medicine
Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P. Bates, G. Bernhard Landwehrmeyer, Andreas Neueder   +8 more
doaj   +1 more source

Gelatin methacryloyl hydrogel as a potential scaffold for cell transplantation for Huntington's disease. [PDF]

Brain Commun
Nguyen L, McCaughey-Chapman A, Connor B.
europepmc   +1 more source

Whole‐Exome Sequencing Reveals the Genetic Landscape and Genotype–Phenotype Spectrum of Dystonia in a Chinese Cohort

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Whole‐exome sequencing of 147 Chinese patients with dystonia revealed an overall molecular diagnostic yield of 33.3%, with higher yields in generalized and childhood‐onset cases. The study expands the genotype–phenotype spectrum of established dystonia genes and provides population‐specific evidence to support genetic evaluation and molecular ...
Yiqing Gong, Huirong Peng, Zhao Chen, Jiawei He, Linliu Peng, Qian Jiang, Chunrong Wang, Linlin Wan, Lang He, Yuting Shi, Rong Qiu, Hong Jiang   +11 more
wiley   +1 more source

Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington's disease. [PDF]

Brain Commun
Osborne GF, Smith EJ, Sathasivam K, Kang Z, Nita IM, Cañibano-Pico M, Phillips J, Bates GP, Landles C.   +8 more
europepmc   +1 more source

CRISPR‐based therapeutic and modelling approaches in Huntington's disease: Progress, challenges and future directions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Clustered regularly interspaced short palindromic repeat (CRISPR) is transforming Huntington's disease research through allele‐selective huntingtin (HTT) targeting, transcriptional and RNA suppression, and advanced disease modelling. Progress towards precision therapy depends on safe central nervous system (CNS) delivery, reduced off‐target and immune ...
Kairat Zhakipbekov, Surayyo Eshkabilova, Zokir Raximov, Sharof Eshonov, Abdusaid Khasanov, Ziyodulla Tokhtamurod, Axmadjan Ashurmetov, Avazbek Abduraxmanov, Niyozbek Abdurakhmonov, Elmurod Eshqobilov, Seyed Mohsen Mirhosseini, Amir Arsalan Ghahari   +11 more
wiley   +1 more source

Biodiversity isn't measured in tons: Making sense of nature in the context of sustainable agriculture

Ecological Applications, Volume 36, Issue 7, October 2026.
Abstract In this review, we articulate several important but often overlooked concepts, trends, and perspectives in the biodiversity monitoring space, specifically in the context of transforming agriculture and the wider food system. We describe the common approaches to biodiversity monitoring—those focused on species, communities, functions, habitats,
Iqbal Singh Bhalla, Philip A. Loring
wiley   +1 more source

Mechanistic Differences in Adult-Onset and Juvenile-Onset Huntington's Disease and the Potential Role of Neurodevelopment. [PDF]

Cureus
Anjur Thupil V, Satchidanand N.
europepmc   +1 more source

Opportunistic Feeding and Parasite Assemblages in Sei Whales (Balaenoptera borealis) From Southern Chile Revealed by DNA Metabarcoding

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study represents the first metabarcoding‐based description of prey composition and parasite‐associated taxa in stranded sei whales from southern South America. ABSTRACT Balaenopterid whales are major consumers in pelagic ecosystems and play a fundamental role in marine food webs.
Daniela Haro, Guillaume Schwob, Luis Bedriñana‐Romano, Valentina Bernal‐Durán, Benjamín Cáceres, Rodrigo Hucke‐Gaete, Miguel Cáceres, Olivia Blank, Camila Calderón‐Quirgas, Mauricio Ulloa, Francisco Viddi   +10 more
wiley   +1 more source

A Cost-Effectiveness Analysis for Treatments of Patients with Early Stage Huntington's Disease in the USA. [PDF]

Pharmacoecon Open
Patil D, Slejko JF, Savitt JM, Mattingly Ii TJ.   +3 more
europepmc   +1 more source

Enzyme‐Digested Edible Bird's Nest Promotes NGF‐Induced Differentiation of PC12 Cells by Activating the TrkA‐ERK1/2‐CREB‐BDNF Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
EBND alone upregulates neurofilament expression but does not induce neurite outgrowth in PC12 cells. With suboptimal NGF, EBND synergistically promotes neuronal differentiation via the TrkA‐ERK1/2‐CREB‐BDNF pathway. This effect is blocked by the TrkA inhibitor GW441756, confirming a TrkA‐dependent mechanism.
Wen Zhang, Xintong Wang, Huiqing Zhu, Xiaoxian Lin, Rongzi Li, Man Yuan, Baocai Xu, Dongliang Wang, Wei Xiong, Yixuan Li   +9 more
wiley   +1 more source