Results 191 to 200 of about 4,904,701 (256)

In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging. [PDF]

Elife
Ioakeimidis V, Palombo M, Casella C, Layland L, McNabb C, Schubert R, Pallmann P, Busse M, Drew C, Alusi S, Harrower T, Davies J, Rosser A, Metzler-Baddeley C.   +13 more
europepmc   +1 more source

Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn, Jin‐Soo Kim, Daniel A. Galvao, Dennis R. Taaffe, Dong Hyun Yoon, Carolyn McIntyre, Christelle Schofield, Yoon Jung Chang, Jihee Min, Wook Song, Robert U. Newton   +10 more
wiley   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington's disease. [PDF]

Transl Neurodegener
Favagrossa M, Passoni A, Valenza M, Di Prisco D, Birolini G, Villa M, Scolz A, Pasetto L, Bonetto V, Zuccato C, Mariotti C, Bagnati R, Cattaneo E, Colombo L, Salmona M.   +14 more
europepmc   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington's disease. [PDF]

Brain
Ishtayeh H, Battistoni E, Pochtar S, McHugh TLM, Tshilenge KT, Rossmiller B, Amer-Sarsour F, Berdichevsky Y, Muchtar N, Weil M, Ellerby LM, Ashkenazi A.   +11 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Metabolic reprogramming is critical to microglial activation in Huntington's disease. [PDF]

JCI Insight
Jauhari A, Monek AC, Abakumova OS, Singh T, Singh S, Wang X, Clise CS, Carlisle DL, Friedlander RM.   +8 more
europepmc   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source