Results 211 to 220 of about 10,552,439 (323)

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease

Journal of Clinical Investigation, 2017
Su Yang, Renbao Chang, Huiming Yang, Ting Zhao, Yan Hong, H. Kong, Xiaobo Sun, Zhaohui Qin, P. Jin, Shihua Li, Xiao-Jiang Li   +10 more
semanticscholar   +1 more source

Advancing Quantitative Susceptibility Mapping With 2.5D Diffusion Models for Rapid Intracranial Hemorrhage Quantification

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 596-610, August 2026.
ABSTRACT Purpose To develop a generative diffusion model‐based approach for robust and efficient quantitative susceptibility mapping (QSM) reconstruction in intracranial hemorrhage (ICH), applicable to both standard gradient echo (GRE) and rapid echo planar imaging (EPI) acquisitions.
Zhuang Xiong, Yang Gao, Feng Liu, Derek Emery, Ken Butcher, Alan H. Wilman, Hongfu Sun   +6 more
wiley   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder, Asmar Ahsan, Pitchapa Bubphachat, Khadiza Akter, Jeffrey K. Huang, Chi‐Chen Sarah Huang   +5 more
wiley   +1 more source

Bridging the gap: sex-specific differences in Huntington's disease. [PDF]

Orphanet J Rare Dis
Hemicker G, Schwarzová K, Labrecque S, Cerejo C, Carbone F, Peball M, Wimmer B, Mahlknecht P, Krismer F, Djamshidian A, Seppi K, Heim B.   +11 more
europepmc   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Treatment of Huntington's disease with a pan-HTT-targeting CRISPR nuclease. [PDF]

Mol Ther
Tan K, Del Bosque Siller D, Xiong AY, Wang AXA, McCallister TX, Mummadi S, St John LA, Lee TK, Carrillo AN, Renshaw DG, Zhou RH, Lim CKW, He J, Fields CJ, Hayden MR, Gaj T.   +15 more
europepmc   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, Volume 13, Issue 7, Page 1452-1466, July 2026.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Longitudinal trajectories of apathy in Huntington's disease: a 6-year follow-up study. [PDF]

J Neurol
Poulsen E, Hendel RK, Ásbjörnsdóttir B, Hjermind LE, Nielsen JE, Vogel A.   +5 more
europepmc   +1 more source

The Prevalence of Huntington's Disease

Neuroepidemiology, 2016
M. Rawlins, N. Wexler, A. Wexler, S. Tabrizi, I. Douglas, S. Evans, L. Smeeth   +6 more
semanticscholar   +1 more source