Results 61 to 70 of about 10,552,439 (323)

Test–Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study

Frontiers in Psychology, 2018
Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) across multiple domains.
Clare E. Palmer, Douglas Langbehn, Sarah J. Tabrizi, Marina Papoutsi   +3 more
doaj   +1 more source

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source

Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]

Journal of Integrative Neuroscience, 2020
Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
doaj   +1 more source

Additional file 1: of Unmet needs for healthcare and social support services in patients with Huntingtonâ s disease: a cross-sectional population-based study

, 2015
The Needs and Provision Complexity Scale. (PDF 102 kb)
van Walsem, Marleen, Howe, Emilie, Iversen, Kristin, Frich, Jan, Andelic, Nada   +4 more
openaire   +1 more source

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

Cell, 2019
Summary Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from the length of huntingtin’s polyglutamine segment, dictates the rate at which Huntington’s disease (HD) develops ...
Jong-Min Kevin Jacob Kyung-Hee Douglas Eun Pyo Michael J. J Lee Correia Loupe Kim Barker Hong Chao Long Lucent, Jong-Min Lee, Kevin Correia, Jacob M. Loupe, Kyung-Hee Kim, Douglas D. Barker, E. Hong, M. Chao, Jeffrey D. Long, D. Lucente, J. P. Vonsattel, R. M. Pinto, Kawther Abu Elneel, E. Ramos, J. Mysore, T. Gillis, V. Wheeler, M.E Macdonald, James F. Gusella, Branduff McAllister, Tom Massey, C. Medway, T. Stone, L. Hall, Lesley Jones, P. Holmans, S. Kwak, A. Ehrhardt, Cristina Sampaio, Marc Ciosi, Alastair Maxwell, A. Chatzi, D. Monckton, Michael Orth, G. B. Landwehrmeyer, J. Paulsen, E. Dorsey, Ira Shoulson, Richard H. Myers   +38 more
semanticscholar   +1 more source

A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse [PDF]

, 2006
Neural stem and progenitor cells are located in the subependyma of the adult forebrain. An increase in adult subependymal cell proliferation is reported after various kinds of brain injury.
Batista, C.M.C., Akamatsu, W., Shimabukuro, M.K., Kippin, T.E., Willaime-Morawek, S., van der Kooy, D.   +5 more
core   +1 more source

Huntington’s Disease [PDF]

, 2021
Huntington’s disease is a neurodegenerative disorder with progressive motor, cognitive, and neuropsychiatric impairments. There is evidence that problems in both motor speech and language affect individuals’ ability to use language for active ...
Hartelius, Lena,, Lena Hartelius, Ulrika Ferm, Charlotta Saldert, Saldert, Charlotta,, Ferm, Ulrika,   +5 more
core   +1 more source

Additional file 6: Figure S2. of Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntingtonâ s disease are not reflected in mutant Huntingtin inclusion prevalence

, 2015
Analysis of the overlap of changes in gene expression in the YAC128 striatum at A. 6 months of age B. 12 months of age and C. 18 months of age compared with other HD model mouse striata and human brain. Frequency represents the fraction of the top 200 HdhQ150 expression changes that map to a particular bin of ranked data (1000 genes per bin) in the ...
Zubeyde Bayram-Weston, Stone, Timothy, Giles, Peter, Elliston, Linda, Nari Janghra, Higgs, Gemma, Holmans, Peter, Dunnett, Stephen, Brooks, Simon, Jones, Lesley   +9 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source