Results 61 to 70 of about 4,904,701 (256)

Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series

Brain Sciences, 2020
Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington’s disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric symptoms, often ...
Jannis Achenbach, Charlotte Thiels, Thomas Lücke, Carsten Saft   +3 more
doaj   +1 more source

Metal Compound‐Based Non‐Enzymatic Electrochemical Cholesterol Sensors: Emerging Materials and Mechanistic Insights

Advanced Materials Interfaces, EarlyView.
This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin, Chao‐Tsen (Rora) Chen, Jacopo Giaretta, Thanh‐Qua Nguyen, Hoang‐Phuong Phan, Fariba Dehghani, Syamak Farajikhah   +6 more
wiley   +1 more source

Visual control improves the accuracy of hand positioning in Huntington’s disease

Aktualności Neurologiczne, 2017
Background: The study aimed at demonstrating dependence of visual feedback during hand and finger positioning task performance among Huntington’s disease patients in comparison to patients with Parkinson’s disease and cervical dystonia.
Emilia J. Sitek, Witold Sołtan, Agnieszka Konkel, Dariusz Wieczorek, Michał Schinwelski, Piotr Robowski, Jarosław Sławek   +6 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

The breaking point where repeat expansion triggers neuronal collapse in Huntington’s disease

Cell Genomics
Somatic CAG expansion drives neuronal loss in Huntington’s disease (HD), but how expansion results in pathogenesis has remained unclear. Handsaker et al.1 use single-cell RNA and repeat length sequencing to reveal a phased model of expansion and toxicity,
Michael D. Flower, Sarah J. Tabrizi
doaj   +1 more source

Postoperative hematoma in cervical spondylosis patient complicated with Huntington’s disease: Case report and literature review

SAGE Open Medical Case Reports, 2023
Hematoma is a life-threatening complication of anterior surgery in cervical spondylosis patients. Herein, we report a cervical spondylosis patient complicated with Huntington’s disease, who developed unexpected neck hematoma after anterior cervical ...
Zifan Zhang, Chen Xu, Guoqing Wen, Minjie Dong, Xiaolong Shen, Baofeng Gong, Baifeng Sun, Min Qi, Ye Tian, Yang Liu, Wen Yuan   +10 more
doaj   +1 more source

Juvenile Huntington’s disease

Анналы клинической и экспериментальной неврологии, 2017
Juvenile Huntingtons disease (JHD) manifests in 1st2nddecades of life and accounts for 29% of all cases ofHuntingtons disease; its pathogenic mechanisms are related togenetic anticipation and imprinting.
G. E. Rudenskaya, D. A. Savvin, V. P. Fedotov, S. A. Kurbatov, A. V. Polyakov, N. M. Galeeva   +5 more
doaj   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

PLoS ONE, 2015
Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis.
James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi   +3 more
doaj   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source