Results 21 to 30 of about 10,552,439 (323)

Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington’s Disease

Frontiers in Neurology, 2021
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions.
Nina M. Mansoor, Tishok Vanniyasingam, Ian Malone, Nicola Z. Hobbs, Elin Rees, Alexandra Durr, Raymund A. C. Roos, Bernhard Landwehrmeyer, Sarah J. Tabrizi, Eileanoir B. Johnson, Rachael I. Scahill   +10 more
doaj   +1 more source

Exploring the structural relationship between interviewer and self-rated affective symptoms in Huntington’s disease [PDF]

, 2016
This study explores the structural relationship between self-report and interview measures of affect in Huntington’s disease. The findings suggest continued use of both to recognize the multidimensionality within a single common consideration of ...
Dale M, Ferraldeschi M, Underwood M, Rickards H, REGISTRY Investigators of the European Huntington’s Disease Network, Callaghan J, Romano S, Ristori G., Maltby J   +8 more
core   +3 more sources

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype [PDF]

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical
Lopes-Cendes, Iscia, Odile Russaouen, Cécile Cazeneuve, Cazeneuve, Cécile, Walker R.H., Russaouen O., Bader B., Guilherme Riccioppo Rodrigues, Brice A., Russaouen, Odile, Tumas, Vitor, Wilson Marques Jr., Rodrigues G.R., Iscia Lopes-Cendes, Danek, Adrian, Adrian Danek, MARQUES JR., Wilson, Brice, Alexis, Marques Jr. W., Marques, Wilson, Vitor Tumas, Walker, Ruth H., Bader, Benedikt, Benedikt Bader, Danek A., Cazeneuve C., Ruth H. Walker, Riccioppo Rodrigues, Guilherme, RODRIGUES, Guilherme Riccioppo, Alexis Brice, Tumas V., Lopes-Cendes I.   +31 more
core   +1 more source

The personal experience of parenting a child with Juvenile Huntington’s Disease: perceptions across Europe [PDF]

, 2013
The study reported here presents a detailed description of what it is like to parent a child with juvenile Huntington’s disease in families across four European countries. Its primary aim was to develop and extend findings from a previous UK study.
Jonathan A Smith, Tibben, A., Ferdinando Squitieri, Bernhard Landwehrmeyer, Krysa, W., Marie-Louise Goller, Helen Santini, ‘Annunziata’ de Nicola, Oliver Quarrell, Petrollini, M., Matteo Paduanello, Landwehrmeyer, B., de Nicola, A., Virginia Eatough, Christine Eiser, Paduanello, M., Santini, H., Lee Weille, K., Aad Tibben, Smith, Jonathan A., Maria Rakowicz, Quarrell, O., Katie Lee Weille, Squitieri, F., Rakowicz, M., Eiser, C., Eatough, Virginia, Wioletta Krysa, Martina Petrollini, Goller, M.-L.   +29 more
core   +1 more source

Juvenile Onset Huntington's Disease [PDF]

, 2021
The Special Issue “Juvenile Onset Huntington’s Disease” highlights the growing interest in understanding the unique aspects of this ultra-rare disorder.

core   +1 more source

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline [PDF]

, 2010
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests.
Brunner Daniela, Menalled Liliana B., Brunner, D., Signer Ethan, Liliana B Menalled, Benjamin Zahasky, Ragland Natalie, Tobin Allan J., Allan J Tobin, Larry Park, Ragland, N., Minnich, J., Leeds, J., Daniela Brunner, Jennifer Goodman, Zahasky, B., Signer, E., Leeds Janet, Howland David, Zahasky Benjamin, Goodman, J., Tobin, A.J., Patry Monica, Minnich Jennie, Ethan Signer, Goodman Jennifer, Patry, M., Menalled, L.B., Lowden, Philip A.S., Jennie Minnich, Park Larry, Phillip A S Lowden, Howland, D., Park, L., Janet Leeds, Monica Patry, Lowden Phillip A. S., David Howland, Natalie Ragland   +38 more
core   +1 more source

Predicting clinical scores in Huntington’s disease: a lightweight speech test [PDF]

, 2022
OBJECTIVES: Using brief samples of speech recordings, we aimed at predicting, through machine learning, the clinical performance in Huntington’s Disease (HD), an inherited Neurodegenerative disease (NDD). METHODS: We collected and analyzed 126 samples of
Montillot, Justine, Cleret de Langavant, Laurent, Cao, Xuan-Nga, Dupoux, Emmanuel, Youssov, Katia, Lunven, Marine, Hamet Bagnou, Jennifer, Bachoud-Lévi, Anne-Catherine, Titeux, Hadrien, Riad, Rachid, Lemoine, Laurie, Sliwinski, Agnes   +11 more
core   +1 more source

22 Years of predictive testing for Huntington’s disease : the experience of the UK Huntington’s Prediction Consortium [PDF]

, 2017
"22 Years of predictive testing for Huntington’s disease: the experience of the UK Huntington’s Prediction Consortium" European Journal of Human Genetics (2016) 24, 1515; doi:10.1038/ejhg.2016.81 Corrigendum: 15 September 2016 European Journal of Human ...
Quarrell, Oliver W, UK Huntington’s Disease Prediction Consortium   +1 more
core   +1 more source

Exploring the Reliability and Validity of the Huntington’s Disease Quality of Life Battery for Carers (HDQoL-C) within A Polish Population [PDF]

, 2019
Huntington’s disease (HD) is a rare genetic neurodegenerative disorder that causes motor disorders, neuropsychiatric symptoms and a progressing deterioration of cognitive functions.
Aubeeluck, Aimee, ?lusarska, Barbara, Aubeeluck, Aimeee, Stupple, Edward, Bartoszek, Adrian, Adrian Bartoszek, Barbara Ślusarska, Edward Stupple, Katarzyna Kocka, Kocka, K, Ślusarska, B, Stupple, Edward J. N., Bartoszek, Agnieszka, Kocka, Katarzyna, Aimee Aubeeluck, Bartoszek, A, Agnieszka Bartoszek   +16 more
core   +2 more sources

Molecular Pathophysiological Mechanisms in Huntington’s Disease

Biomedicines, 2022
Huntington’s disease is an inherited neurodegenerative disease described 150 years ago by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG repeat on exon 1 of the huntingtin gene located on chromosome 4. In the following
Anamaria Jurcău
semanticscholar   +1 more source