Results 301 to 310 of about 9,130,139 (414)

Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long‐Term Functional Evaluation

Cell Proliferation, EarlyView.
We optimised a protocol that combines developmental patterning with mechanical cut to produce pint‐sized midbrain organoids, with diameters less than 300 μm, suitable for long‐term evaluation, along with a comprehensive functional assay system consisting of calcium transient assay, neurite extension assay, and multielectrode array assay. ABSTRACT Human
Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang Hu   +7 more
wiley   +1 more source

Huntington’s Disease

Cold Spring Harbor symposia on quantitative biology, 1996
Shutish C. Patel, Kamlesh Asotra, Yogesh C. Patel   +2 more
openaire   +5 more sources

Symptomatic Treatment of Huntington Disease

, 2008
Octavian Adam, Joseph Jankovic
openalex   +1 more source

Early autophagic response in a novel knock-in model of Huntington disease [PDF]

, 2010
Mary Y. Heng, Duy K. Duong, Roger L. Albin, Sara J. Tallaksen‐Greene, Jesse M. Hunter, Mathieu Lesort, Alex Osmand, Henry L. Paulson, Peter J. Detloff   +8 more
openalex   +1 more source

Targeting H3K4 trimethylation in Huntington disease

Proceedings of the National Academy of Sciences of the United States of America, 2013
Malini Vashishtha, C. Ng, F. Yildirim, T. A. Gipson, I. H. Kratter, L. Bodai, Wan-Doo Song, Alice L. Lau, Adam T. Labadorf, Annie Vogel-Ciernia, Juan C. Troncosco, C. Ross, G. Bates, D. Krainc, Ghazaleh Sadri‐Vakili, S. Finkbeiner, J. Marsh, D. Housman, E. Fraenkel, L. Thompson   +19 more
semanticscholar   +1 more source

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

Cell Proliferation, EarlyView.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing, Siqi Yang, Yuchao Liang, Pengwei Hu, Bingjie Dai, Hanshuang Li, Yongqiang Xing, Yongchun Zuo   +7 more
wiley   +1 more source

β-Blocker Use and Delayed Onset and Progression of Huntington Disease.

JAMA Neurol
Schultz JL, Ogilvie AC, Harshman LA, Nopoulos PC.   +3 more
europepmc   +1 more source

Postmortem neuropathology in early Huntington disease. [PDF]

J Neuropathol Exp Neurol
Hedreen JC, Berretta S, White Iii CL.
europepmc   +1 more source

Genetic adverse selection: Evidence from long-term care insurance and Huntington disease [PDF]

, 2010
Emily Oster, Ira Shoulson, Kimberly A. Quaid, E. Ray Dorsey   +3 more
openalex   +1 more source

A closer look at Doleac and Mukherjee (2022) and the effects of naloxone access laws on opioid ER admissions

Economic Inquiry, EarlyView.
Abstract In their 2022 study, ‘The Effects of Naloxone Access Laws on Opioid Abuse, Mortality, and Crime,’ Doleac and Mukherjee conclude that broadening access to a life‐saving drug—naloxone—does not reduce opioid‐related mortality as the drug simultaneously encourages riskier drug use. I show issues with their data, design, and estimation methods. For
Sergey Alexeev
wiley   +1 more source