Results 301 to 310 of about 9,201,564 (391)

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

open access: yesThe FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser   +9 more
wiley   +1 more source

Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease. [PDF]

open access: yesNeurol Ther
Frank S   +15 more
europepmc   +1 more source

A role for autophagy in Huntington's disease

open access: yesNeurobiology of Disease, 2019
Katherine R. Croce, Ai Yamamoto
semanticscholar   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

open access: yesThe FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman   +13 more
wiley   +1 more source

Huntington disease alters the actionable information in plasma extracellular vesicles. [PDF]

open access: yesClin Transl Med
Neueder A   +10 more
europepmc   +1 more source

Mouse models of Huntington disease: variations on a theme

open access: green, 2009
Dagmar E. Ehrnhoefer   +3 more
openalex   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

open access: yesThe FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya   +1 more
wiley   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

open access: yesThe FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka   +3 more
wiley   +1 more source

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