Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser+9 more
wiley +1 more source
Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease. [PDF]
Frank S+15 more
europepmc +1 more source
A role for autophagy in Huntington's disease
Katherine R. Croce, Ai Yamamoto
semanticscholar +1 more source
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman+13 more
wiley +1 more source
Huntington disease alters the actionable information in plasma extracellular vesicles. [PDF]
Neueder A+10 more
europepmc +1 more source
Mouse models of Huntington disease: variations on a theme
Dagmar E. Ehrnhoefer+3 more
openalex +1 more source
Type I interferon signalling and interferon‐responsive microglia in health and disease
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya+1 more
wiley +1 more source
Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease. [PDF]
Ferguson R+4 more
europepmc +1 more source
A guide to heat shock factors as multifunctional transcriptional regulators
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka+3 more
wiley +1 more source
Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease. [PDF]
Shah A, Fuller S, Criswell S, Apte RS.
europepmc +1 more source